Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 5/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.50 |
| ▸ | CCKBR | P32239 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11730151 | 0.84 | OPRK1 (0.48) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11813367 | 0.84 | GABRA5 (0.59) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11734238 | 0.84 | OPRK1 (0.67) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11733771 | 0.83 | GABRA1 (0.44) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11730859 | 0.83 | GABRA3 (0.45) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11825387 | 0.81 | CHRM1 (0.49) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11830483 | 0.81 | GABRA1 (0.58) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11845687 | 0.81 | CHRM1 (0.49) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11732705 | 0.80 | OPRK1 (0.39) | GABRA5GABRA2GABRB2GABRA1GABRA3 | |
| SCHEMBL11826370 | 0.79 | LMNA (0.61) | GABRA5GABRA2GABRB2GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523846-A2 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1993-01-20 | — | — | EP | disclosed |
| EP-0272866-A1 | 1,4-Benzodiazepines with 5-membered heterocyclic rings | MERCK & CO. INC. (US) | 1988-06-29 | — | — | EP | disclosed |
| US-4001261-A | Process for the production of 1-[(dimethylamino)methyl]-6-phenyl-4H-imidazo[1,2-a][1,4]-benzodiazepine | THE UPJOHN COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3992408-A | CHEMICAL INTERMEDIATES | THE UPJOHN COMPANY (US) | 1976-11-16 | — | — | US | disclosed |
| US-3941803-A | 2-(Imidazol-1-yl)benzophenones | THE UPJOHN COMPANY (US) | 1976-03-02 | — | — | US | disclosed |
| US-3910946-A | 4H-Imidazo{8 1,2-a{9 {8 1,4{9 benzodiazepines | UPJOHN CO | 1975-10-07 | — | — | US | disclosed |