SCHEMBL9566646

SCHEMBL9566646

Nc1cccc(C(=O)c2ccc(Nc3ccc4c(c3)C(=O)NC4=O)cc2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PBRM1 Q86U86 1/20 0.50
RXFP1 Q9HBX9 1/20 0.49
KMT2A Q03164 8/20 0.48
MEN1 O00255 5/20 0.46
POLB P06746 2/20 0.46
CTDSP1 Q9GZU7 2/20 0.46
ATM Q13315 1/20 0.45
NPC1 O15118 1/20 0.45
MITF O75030 1/20 0.45
LMNA P02545 1/20 0.45
CASP3 P42574 2/20 0.44
MAPK13 O15264 2/20 0.44
MAPK12 P53778 2/20 0.44
MAPK11 Q15759 2/20 0.44
MAPK14 Q16539 2/20 0.44
CA1 P00915 1/20 0.43
CA2 P00918 1/20 0.43
CA9 Q16790 1/20 0.43
PDPK1 O15530 1/20 0.42
KDM4E B2RXH2 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29577357 0.87 PBRM1 (0.57) PBRM1RXFP1KMT2AMEN1POLB
SCHEMBL9566671 0.82 ATM (0.55) RXFP1KMT2AMEN1POLBCTDSP1
SCHEMBL9566653 0.78 KMT2A (0.49) KMT2AMEN1CTDSP1ATMLMNA
SCHEMBL6653992 0.77 MAPK13 (0.71) PBRM1KMT2AMEN1POLBATM
SCHEMBL9566666 0.76 ATM (0.75) KMT2AMEN1POLBATMALDH1A1
SCHEMBL14514337 0.75 DDX3X (0.66) RXFP1KMT2AMEN1POLBCTDSP1
SCHEMBL11422252 0.75 ATM (0.53) PBRM1RXFP1KMT2AMEN1ATM
SCHEMBL28344097 0.75 KMT2A (0.44) RXFP1KMT2AMEN1CTDSP1ATM
SCHEMBL29492473 0.74 PBRM1 (0.88) PBRM1KMT2AMEN1POLBATM
SCHEMBL203373 0.74 PBRM1 (0.88) PBRM1KMT2AMEN1POLBATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0530707-A1 Method for preparing polyamide-imides EASTMAN KODAK COMPANY (US) 1993-03-10 EP claimed
EP-0530707-A1 Method for preparing polyamide-imides EASTMAN KODAK COMPANY (US) 1993-03-10 EP disclosed