Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | XPO1 | O14980 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568787 | 0.81 | HSD11B1 (0.46) | POLBPIN1KMT2AHSD17B10ALDH1A1 | |
| SCHEMBL9469455 | 0.76 | OGT (0.41) | KDM4EHSD17B10ALDH1A1SMN1; SMN2SLC6A2 | |
| SCHEMBL8947234 | 0.75 | POLB (0.60) | POLBXPO1KMT2AALDH1A1SLC6A2 | |
| SCHEMBL9568794 | 0.74 | ALDH1A1 (0.51) | KDM4EHSD17B10ALDH1A1PTGS2CYP1A2 | |
| SCHEMBL8947354 | 0.73 | POLB (0.65) | POLBXPO1KMT2AKDM4EHSD17B10 | |
| SCHEMBL8791363 | 0.73 | NQO2 (0.42) | POLBKMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9568756 | 0.70 | POLB (0.57) | POLBXPO1KMT2AKDM4EHSD17B10 | |
| SCHEMBL8790766 | 0.69 | KMT2A (0.48) | KMT2AKDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL7114830 | 0.69 | BRD4 (0.40) | KMT2AKDM4EHSD17B10PTGS2MEN1 | |
| SCHEMBL9568778 | 0.69 | SIGMAR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262433-A | Antidiabetic agents | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0528277-A1 | Tetrazoleacetic acid derivatives aldose reductase inhibitors | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1993-02-24 | — | — | EP | disclosed |