Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.50 |
| ▸ | RARB | P10826 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9568787 | 0.79 | HSD11B1 (0.46) | HSD11B1PTGS2ALDH1A1HSD17B10 | |
| SCHEMBL9568794 | 0.78 | ALDH1A1 (0.51) | HSD11B1PTGS2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8791911 | 0.77 | MAPT (0.33) | ALDH1A1 | |
| SCHEMBL8947316 | 0.75 | ALDH1A1 (0.63) | HSD11B1RARBALDH1A1HPGDHSD17B10 | |
| SCHEMBL8947063 | 0.75 | ALDH1A1 (0.46) | HSD11B1ALDH1A1HPGD | |
| SCHEMBL9568720 | 0.72 | MAPK1 (0.43) | HSD11B1ALDH1A1HPGD | |
| SCHEMBL8947078 | 0.71 | ALDH1A1 (0.60) | HSD11B1RARBALDH1A1HPGD | |
| SCHEMBL8791602 | 0.71 | L3MBTL1 (0.40) | ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8947288 | 0.71 | — | — | |
| SCHEMBL7114830 | 0.70 | BRD4 (0.40) | PTGS2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262433-A | Antidiabetic agents | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0528277-A1 | Tetrazoleacetic acid derivatives aldose reductase inhibitors | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1993-02-24 | — | — | EP | disclosed |