Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | CMA1 | P23946 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690103 | 0.85 | ALDH1A1 (0.43) | ALDH1A1HPGDTSHRHSD11B1HSD17B10 | |
| SCHEMBL9568708 | 0.83 | MAPK1 (0.37) | ALDH1A1HPGDTSHRHSD11B1HSD17B10 | |
| SCHEMBL9469700 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDKDM4CCMA1TSHR | |
| SCHEMBL9689917 | 0.74 | ALDH1A1 (0.48) | ALDH1A1HPGDKDM4CCMA1TSHR | |
| SCHEMBL5966693 | 0.74 | ALDH1A1 (0.74) | ALDH1A1HPGDKDM4CTSHRALOX15 | |
| SCHEMBL8791207 | 0.72 | ALDH1A1 (0.65) | ALDH1A1HPGDKDM4CTSHRHSD11B1 | |
| SCHEMBL9469451 | 0.72 | ALDH1A1 (0.62) | ALDH1A1HPGDKDM4CHSD11B1TDP1 | |
| SCHEMBL8947261 | 0.72 | ALDH1A1 (0.75) | ALDH1A1HPGDKDM4CALOX15HSD11B1 | |
| SCHEMBL9568844 | 0.72 | KDM4E (0.51) | ALDH1A1HPGDKDM4CTSHRALOX15 | |
| SCHEMBL8947331 | 0.71 | ALDH1A1 (0.84) | ALDH1A1HPGDKDM4CHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262433-A | Antidiabetic agents | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-11-16 | — | — | US | disclosed |
| EP-0528277-A1 | Tetrazoleacetic acid derivatives aldose reductase inhibitors | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1993-02-24 | — | — | EP | disclosed |