Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 2/20 | 0.44 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 3/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983231 | 0.85 | HDAC1 (0.48) | HDAC1CCR2FBP1EPHX2ALOX5 | |
| SCHEMBL9569784 | 0.80 | HDAC1 (0.46) | HDAC1FBP1CA12CA1CA9 | |
| SCHEMBL9569793 | 0.77 | EPHX2 (0.48) | HDAC1CCR2CA12CA1CA9 | |
| SCHEMBL9424688 | 0.75 | EPHX1 (0.51) | FBP1CA12CA1CA9EPHX2 | |
| SCHEMBL18029666 | 0.75 | NLRP3 (0.55) | CCR2FBP1 | |
| SCHEMBL19869285 | 0.73 | NLRP3 (0.53) | FBP1 | |
| SCHEMBL9424316 | 0.72 | FBP1 (0.52) | FBP1CA9EPHX2NPC1CA2 | |
| SCHEMBL5804272 | 0.72 | NTRK1 (0.62) | HDAC1FBP1CA2GAAMAPT | |
| SCHEMBL9424579 | 0.72 | EPHX1 (0.53) | CA12CA1CA9EPHX2NPC1 | |
| SCHEMBL9836719 | 0.71 | CA2 (0.58) | HDAC1CCR2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560554-A2 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5169860-A | Benzofuran or benzothiophene arylsulfonylureas | ELI LILLY AND COMPANY (US) | 1992-12-08 | — | — | US | disclosed |