Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | NOS2 | P35228 | 4/20 | 0.40 |
| ▸ | NOS3 | P29474 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9598614 | 0.84 | AURKA (0.43) | AURKAKMT2APOLBNOS1NOS2 | |
| SCHEMBL9851464 | 0.83 | NOS3 (0.49) | AURKAKMT2APOLBNOS1NOS2 | |
| SCHEMBL13155057 | 0.81 | AURKA (0.47) | AURKAKMT2APOLBNOS1NOS2 | |
| SCHEMBL12841752 | 0.74 | AURKA (0.49) | AURKAPOLBNOS1NOS2NOS3 | |
| SCHEMBL9569994 | 0.73 | METAP2 (0.42) | NOS1NOS2NOS3CYP2C9 | |
| SCHEMBL2756735 | 0.73 | SMN1; SMN2 (0.67) | AURKAPOLBNOS1NOS2NOS3 | |
| SCHEMBL15451032 | 0.70 | AURKA (0.49) | AURKAKMT2ANOS1NOS2NOS3 | |
| SCHEMBL9570423 | 0.70 | CYP2C9 (0.53) | AURKAKMT2ANOS1NOS2SMN1; SMN2 | |
| SCHEMBL9569990 | 0.69 | KMT2A (0.58) | KMT2APOLBSMN1; SMN2MEN1NPC1 | |
| SCHEMBL29623095 | 0.69 | PIN1 (0.55) | AURKASMN1; SMN2ALDH1A1MAPK10RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270322-A | Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1993-12-14 | — | — | US | disclosed |
| EP-0555825-A1 | Imidazo(1,2-a)pyridines as angiotensin-II-antagonists | Dr. Karl Thomae GmbH (DE) | 1993-08-18 | — | — | EP | disclosed |