Bestatin Methyl Ester

Bestatin Methyl Ester

SCHEMBL9574604

COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](O)[C@H](N)Cc1ccccc1

nearest known ligand 0.68

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ ANPEP P15144 2/20 0.61
▸ BIRC2 Q13490 1/20 0.61
▸ IL1RN P18510 5/20 0.60
▸ ERAP2 Q6P179 5/20 0.60
▸ ERAP1 Q9NZ08 4/20 0.60
▸ LAP3 P28838 2/20 0.57
▸ RNPEP Q9H4A4 1/20 0.57
▸ DNPEP Q9ULA0 1/20 0.57
▸ ALDH1A1 P00352 1/20 0.55
▸ THRB P10828 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ HSD17B10 Q99714 1/20 0.55
▸ LTA4H P09960 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bestatin Methyl Ester SCHEMBL15261304 1.00 ANPEP (0.61) ANPEPBIRC2IL1RNERAP2ERAP1
Bestatin Methyl Ester SCHEMBL12381043 1.00 ANPEP (0.61) ANPEPBIRC2IL1RNERAP2ERAP1
SCHEMBL17278281 0.91 METAP2 (0.55) ANPEPBIRC2IL1RNERAP2ERAP1
SCHEMBL22703104 0.91 LAP3 (0.55) ANPEPBIRC2IL1RNERAP2ERAP1
SCHEMBL24036408 0.91 LAP3 (0.55) ANPEPBIRC2IL1RNERAP2ERAP1
SCHEMBL30906720 0.90 IL1RN (0.63) ANPEPBIRC2IL1RNERAP2ERAP1
Ubenimex SCHEMBL5807154 0.89 MME (0.66) ANPEPLAP3RNPEPDNPEPLTA4H
Ubenimex SCHEMBL22632072 0.89 MME (0.66) ANPEPLAP3RNPEPDNPEPLTA4H
Ubenimex SCHEMBL7944 0.89 MME (0.66) ANPEPLAP3RNPEPDNPEPLTA4H
Ubenimex SCHEMBL25971 0.89 MME (0.66) ANPEPLAP3RNPEPDNPEPLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026099594-A1 THERAPEUTIC BIFUNCTIONAL AGENTS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2026-05-15 — — WO claimed
JP-5310668-A — — None — — JP disclosed
WO-2026099594-A1 THERAPEUTIC BIFUNCTIONAL AGENTS INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (GB) 2026-05-15 — — WO disclosed
WO-2025216628-A1 PROTAC COMPOUNDS UNIVERSITEIT LEIDEN (NL) 2025-10-16 — — WO disclosed
US-20240226113-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF KUMQUAT BIOSCIENCES INC. 2024-07-11 — — US disclosed
US-20240226113-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF KUMQUAT BIOSCIENCES INC. 2024-07-11 — — US disclosed
US-20240117450-A1 POWDERY MILDEW MARKERS FOR CANNABIS PHYLOS BIOSCIENCE, INC. (US) 2024-04-11 — — US disclosed
WO-2024059041-A1 BENZO-FUSED N-HETEROCYCLES AND USES THEREOF KUMQUAT BIOSCIENCES, INC. (US) 2024-03-21 — — WO disclosed
US-11912708-B2 Macrocyclic heterocycles and uses thereof KUMQUAT BIOSCIENCES INC. (US) 2024-02-27 — — US disclosed
US-11912708-B2 Macrocyclic heterocycles and uses thereof KUMQUAT BIOSCIENCES INC. (US) 2024-02-27 — — US disclosed
US-9861601-B2 Treatment of pulmonary arterial hypertension with leukotriene inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2018-01-09 — — US disclosed
US-20160193168-A1 Treatment of Pulmonary Arterial Hypertension with Leukotriene Inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2016-07-07 — — US disclosed
US-20160193168-A1 Treatment of Pulmonary Arterial Hypertension with Leukotriene Inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2016-07-07 — — US disclosed
US-9233089-B2 Treatment of pulmonary hypertension with leukotriene inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2016-01-12 — — US disclosed
US-9233089-B2 Treatment of pulmonary hypertension with leukotriene inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2016-01-12 — — US disclosed
EP-2827849-A1 TREATMENT OF PULMONARY HYPERTENSION WITH LEUKOTRIENE INHIBITORS The Board Of Trustees Of The University Of the Leland Stanford Junior University (US) 2015-01-28 — — EP disclosed
US-20130251787-A1 Treatment of Pulmonary Hypertension with Leukotriene Inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2013-09-26 — — US disclosed
US-20130251787-A1 Treatment of Pulmonary Hypertension with Leukotriene Inhibitors THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2013-09-26 — — US disclosed
WO-2013142369-A1 TREATMENT OF PULMONARY HYPERTENSION WITH LEUKOTRIENE INHIBITORS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2013-09-26 — — WO disclosed
JP-H05310668-A NEW LEUCINE DERIVATIVE AND ANTIALLERGIC AGENT AND ANTI-INFLAMMATORY AGENT CONTAINING THE SAME MEIJI MILK PROD CO LTD 1993-11-22 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130251787-A1 Treatment of Pulmonary Hypertension with Leukotriene Inhibitors LTA4H, LTB4R2, LTB4R ANPEP 826/4885BIRC2 2948/4885IL1RN 637/4885
US-11912708-B2 Macrocyclic heterocycles and uses thereof HRAS, KRAS, TP53 ANPEP 3194/4885BIRC2 426/4885IL1RN 3209/4885
US-20240226113-A1 HETEROCYCLIC COMPOUNDS AND USES THEREOF TP53, HRAS, KRAS ANPEP 3476/4885BIRC2 762/4885IL1RN 3258/4885
US-20160193168-A1 Treatment of Pulmonary Arterial Hypertension with Leukotriene Inhibitors LTA4H, LTB4R2, LTB4R ANPEP 951/4885BIRC2 2478/4885IL1RN 653/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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