Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | ACR | P10323 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 1/20 | 0.32 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9575659 | 0.87 | KIF11 (0.54) | KIF11CES2CES1PRSS1ACR | |
| SCHEMBL10395579 | 0.86 | ESR1 (0.44) | KIF11ELANECES2CES1PRSS1 | |
| SCHEMBL10395593 | 0.82 | MAPT (0.40) | KIF11ELANEMAPTTDP1L3MBTL1 | |
| SCHEMBL18873284 | 0.81 | MAPT (0.39) | KIF11ELANEMAPTTDP1L3MBTL1 | |
| SCHEMBL15834836 | 0.79 | KIF11 (0.43) | KIF11ELANEMAPTTDP1KMT2A | |
| SCHEMBL28459342 | 0.78 | KIF11 (0.66) | KIF11ELANECES2CES1PRSS1 | |
| SCHEMBL9575401 | 0.77 | KMT2A (0.41) | ELANECES2CES1KMT2AATM | |
| SCHEMBL9575396 | 0.76 | LMNA (0.55) | ELANEPRSS1ACRMAPTL3MBTL1 | |
| SCHEMBL9575390 | 0.76 | LDHA (0.41) | ELANECES2CES1MAPTL3MBTL1 | |
| SCHEMBL9575349 | 0.76 | ELANE (0.39) | ELANEKMT2AATMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5266668-A | Substituted phenyl α-fluoroacrylates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-11-30 | — | — | US | disclosed |
| EP-0249867-A2 | Substituted phenyl esters of alpha-fluoroacrylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-12-23 | — | — | EP | disclosed |