Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trimethoprim. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetroxoprim SCHEMBL30075873 | 0.92 | — | — | |
| SCHEMBL9732799 | 0.88 | DHFR (0.58) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL29420800 | 0.88 | DHFR (0.59) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL9465189 | 0.87 | ALDH1A1 (0.58) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL4731560 | 0.86 | CYP2C19 (0.59) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL4182820 | 0.85 | DHFR (0.72) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL28846304 | 0.85 | DHFR (0.63) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL30345188 | 0.85 | CYP2C19 (0.61) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL29674736 | 0.85 | ESR1 (0.63) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 | |
| Trimethoprim SCHEMBL870329 | 0.85 | ALDH1A1 (0.58) | DHFRMEN1SLC22A1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4415924-B1 | METHOD FOR JOINING TWO SHEET-METAL PARTS TOGETHER BY ADHESIVE BONDING AND WELDING | STELLANTIS AUTO SAS (FR) | 2025-10-29 | — | — | EP | claimed |
| EP-4415924-A1 | METHOD FOR JOINING TWO SHEET-METAL PARTS TOGETHER BY ADHESIVE BONDING AND WELDING | Stellantis Auto SAS (FR) | 2024-08-21 | — | — | EP | claimed |
| WO-2024155256-A1 | A NEW ANTIMICROBIAL SUSCEPTIBILITY TEST KIT AND IN-VITRO METHOD | SAKARYA ÜNİVERSİTESİ REKTÖRLÜĞÜ (TR) | 2024-07-25 | — | — | WO | claimed |
| CN-116098909-B | Sulfadimidine trimethoprim suspension and preparation method thereof | 中牧全药(南京)动物药品有限公司 | 2024-05-24 | — | — | CN | claimed |
| WO-2023062296-A1 | METHOD FOR JOINING TWO SHEET-METAL PARTS TOGETHER BY ADHESIVE BONDING AND WELDING | PSA AUTOMOBILES SA (FR) | 2023-04-20 | — | — | WO | claimed |
| US-20160287528-A1 | METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE | CHEMAPHOR INC. (CA) | 2016-10-06 | — | — | US | claimed |
| US-20130156816-A1 | METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE | CHEMAPHOR INC. (CA) | 2013-06-20 | — | — | US | claimed |
| EP-2536293-A1 | METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE | Chemaphor Inc. (CA) | 2012-12-26 | — | — | EP | claimed |
| WO-2011103464-A1 | METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE | CHEMAPHOR INC. (CA) | 2011-08-25 | — | — | WO | claimed |
| US-20260094617-A1 | METHOD OF PROCESSING MULTIMEDIA, ELECTRONIC DEVICE, AND STORAGE MEDIUM | BEIJING ZITIAO NETWORK TECHNOLOGY CO LTD (CN) | 2026-04-02 | — | — | US | disclosed |
| US-12545739-B2 | Compositions and methods for making and using bispecific antibodies | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2026-02-10 | — | — | US | disclosed |
| EP-4415924-B1 | METHOD FOR JOINING TWO SHEET-METAL PARTS TOGETHER BY ADHESIVE BONDING AND WELDING | STELLANTIS AUTO SAS (FR) | 2025-10-29 | — | — | EP | disclosed |
| US-20250325579-A1 | COMPOSITIONS AND METHODS OF USE FOR WOUND HEALING | SYNEDGEN INC (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250261677-A1 | Confirming Diethylcarbamazine Levels using Near-Infrared Spectroscopy Detection in an Extruder | RUBICON SCIENTIFIC, LLC (US) | 2025-08-21 | — | — | US | disclosed |
| US-8337897-B2 | Immediate release pharmaceutical granule compositions and a continuous process for making them | UNIVERSITEIT GENT (BE) | 2012-12-25 | — | — | US | disclosed |
| US-20110240504-A1 | METHOD AND APPARATUS FOR PACKAGING AND DISPENSING PHARMACEUTICALS | APOTEX TECHNOLOGIES INC. (CA) | 2011-10-06 | — | — | US | disclosed |
| WO-2011103464-A1 | METHODS AND COMPOSITIONS FOR USE IN AQUACULTURE | CHEMAPHOR INC. (CA) | 2011-08-25 | — | — | WO | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-20110008454-A1 | IMMEDIATE RELEASE PHARMACEUTICAL GRANULE COMPOSITIONS AND A CONTINUOUS PROCESS FOR MAKING THEM | UNIVERSITEIT GENT (BE) | 2011-01-13 | — | — | US | disclosed |
| WO-1998010774-A2 | USE OF OZONE FOR TREATING DISEASES OF BODY CAVITY TISSUES, AND APPARATUS THEREFORE | RID (RISKIN DEVICES) LTD. (IL) | 1998-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12545739-B2 | Compositions and methods for making and using bispecific antibodies | TNFRSF9, TNFRSF1A, FOLR1 | DHFR 12/4885MEN1 1913/4885SLC22A1 1336/4885 |
| US-20260094617-A1 | METHOD OF PROCESSING MULTIMEDIA, ELECTRONIC DEVICE, AND STORAGE MEDIUM | ELMO1, MTREX, RNMT | DHFR 3087/4885MEN1 1538/4885SLC22A1 4360/4885 |
| US-20250325579-A1 | COMPOSITIONS AND METHODS OF USE FOR WOUND HEALING | PARG, ARGLU1, AREG | DHFR 3163/4885MEN1 3976/4885SLC22A1 3453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.