Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9581355 | 0.93 | HTR7 (0.42) | HTR1DHTR1BHTR1A | |
| SCHEMBL9582397 | 0.91 | DRD3 (0.47) | HTR1DHTR1BHTR1A | |
| SCHEMBL9582120 | 0.90 | HTR1D (0.42) | HTR1DHTR1B | |
| SCHEMBL9582549 | 0.86 | ADRA2A (0.46) | — | |
| SCHEMBL9581681 | 0.84 | SIGMAR1 (0.47) | — | |
| SCHEMBL9582584 | 0.83 | HTR7 (0.47) | HTR1DHTR1BHTR1A | |
| SCHEMBL9582467 | 0.82 | DRD2 (0.47) | HTR1DHTR1B | |
| SCHEMBL9581342 | 0.82 | HTR1B (0.33) | HTR1DHTR1BHRH3HTR1A | |
| SCHEMBL9582464 | 0.81 | DRD2 (0.44) | HTR1DHTR1BHTR1A | |
| SCHEMBL9582778 | 0.79 | ADRA2A (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5256673-A | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-10-26 | — | — | US | disclosed |
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |