Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582267 | 0.93 | HTR7 (0.54) | DRD2DRD4DRD3KMT2AHSD17B10 | |
| SCHEMBL10648783 | 0.92 | DRD2 (0.49) | DRD2DRD4DRD3ADRA2AADRA2B | |
| SCHEMBL10650004 | 0.86 | DRD2 (0.47) | DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL10413339 | 0.86 | DRD2 (0.45) | DRD2DRD4DRD3KMT2AHTR7 | |
| SCHEMBL10412992 | 0.85 | SLC18A3 (0.47) | DRD2DRD4DRD3SIGMAR1 | |
| SCHEMBL9582467 | 0.85 | DRD2 (0.47) | DRD2DRD4DRD3HTR7ADRA2A | |
| SCHEMBL10413887 | 0.85 | DRD2 (0.68) | DRD2DRD4DRD3ADRA1D | |
| SCHEMBL9581356 | 0.84 | KDM4E (0.64) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9582584 | 0.84 | HTR7 (0.47) | KMT2AHSD17B10HTR7ADRA2AADRA2B | |
| SCHEMBL10412977 | 0.84 | SIGMAR1 (0.46) | DRD2DRD4DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144012-B1 | INDOLE DERIVATIVES | MERCK PATENT GmbH (DE) | 1988-03-16 | — | — | EP | disclosed |
| EP-0144012-A1 | Indole derivatives | MERCK PATENT GmbH (DE) | 1985-06-12 | — | — | EP | disclosed |