Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369766 | 0.84 | ABCC9 (0.50) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9587437 | 0.84 | ABCC9 (0.38) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9587196 | 0.79 | ABCC9 (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL9587001 | 0.77 | CA1 (0.39) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9589242 | 0.77 | CA1 (0.39) | ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9587407 | 0.77 | S100A4 (0.36) | — | |
| SCHEMBL9590341 | 0.75 | GFER (0.36) | — | |
| SCHEMBL9589861 | 0.75 | ALDH1A1 (0.42) | — | |
| SCHEMBL9590296 | 0.75 | CA1 (0.43) | — | |
| SCHEMBL9587505 | 0.74 | SLC6A9 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208246-A | Hypotensive, bronchodilator | J. URIACH & CIA. (ES) | 1993-05-04 | — | — | US | claimed |
| EP-0489300-A2 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1992-06-10 | — | — | EP | claimed |
| US-5272170-A | Tetralones with pharmacological activity | J. URIACH & CIA., S.A. (ES) | 1993-12-21 | — | — | US | disclosed |
| US-5208246-A | Hypotensive, bronchodilator | J. URIACH & CIA. (ES) | 1993-05-04 | — | — | US | disclosed |
| EP-0489300-A2 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1992-06-10 | — | — | EP | disclosed |