Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CDC25C | P30307 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | TDP2 | O95551 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GALK1 | P51570 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9565097 | 0.78 | MAPK1 (0.41) | MEN1KMT2AL3MBTL1MAPK1CA1 | |
| SCHEMBL9588129 | 0.78 | CA1 (0.38) | IDO1ALDH1A1CA1CA2CA7 | |
| SCHEMBL9565096 | 0.78 | MAPK1 (0.39) | IDO1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL9587011 | 0.78 | HTT (0.38) | IDO1ALDH1A1ALOX12L3MBTL1MAPT | |
| SCHEMBL27766938 | 0.77 | ALDH1A1 (0.35) | POLBMEN1KMT2ACDC25ACDC25B | |
| SCHEMBL9588923 | 0.76 | CA2 (0.46) | IDO1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL9587825 | 0.75 | ALDH1A1 (0.38) | POLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL9588527 | 0.75 | TDP2 (0.35) | TDP2CA1CA2BACE1 | |
| SCHEMBL3676704 | 0.75 | ACHE (0.38) | POLBMEN1KMT2ACDC25ACDC25B | |
| SCHEMBL24151287 | 0.73 | MAPT (0.38) | POLBMEN1KMT2ACDC25ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5272170-A | Tetralones with pharmacological activity | J. URIACH & CIA., S.A. (ES) | 1993-12-21 | — | — | US | disclosed |
| US-5208246-A | Hypotensive, bronchodilator | J. URIACH & CIA. (ES) | 1993-05-04 | — | — | US | disclosed |
| EP-0489300-A2 | Tetralones with pharmacological activity | J. URIACH & CIA. S.A. (ES) | 1992-06-10 | — | — | EP | disclosed |