SCHEMBL9595183

SCHEMBL9595183

CS(=O)(=O)c1ccc(-n2ccc(=O)cc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 1/20 0.52
ENPP2 Q13822 2/20 0.43
PTGS2 P35354 10/20 0.41
ALOX5 P09917 1/20 0.39
PTGS1 P23219 3/20 0.39
AKR1C3 P42330 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL92862 0.74 KMT2A (0.59) KMT2AALOX5
SCHEMBL28752490 0.73 MGLL (0.62) ENPP2
SCHEMBL8506107 0.73 PTGS2 (0.40) ENPP2PTGS2PTGS1
SCHEMBL2376239 0.72 ENPP2 (0.72) ENPP2PTGS2
SCHEMBL15167579 0.72 CA12 (0.54) KMT2AENPP2PTGS2AKR1C3
SCHEMBL8797691 0.72 MAOA (0.61) KMT2AENPP2
SCHEMBL3433957 0.71 CA2 (0.52) ENPP2PTGS2AKR1C3
SCHEMBL8505532 0.71 LMNA (0.44) PTGS2PTGS1
SCHEMBL20649339 0.70 KMT2A (0.59) KMT2AENPP2
SCHEMBL14282014 0.69 MGLL (0.57) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5254679-A Containing a quaternized nitrogen IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1993-10-19 US disclosed
EP-0164944-A1 Cephalosporin derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1985-12-18 EP disclosed