Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | HTR6 | P50406 | 3/20 | 0.52 |
| ▸ | HTR1D | P28221 | 2/20 | 0.52 |
| ▸ | HTR1B | P28222 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | HTR1E | P28566 | 2/20 | 0.52 |
| ▸ | HTR7 | P34969 | 2/20 | 0.52 |
| ▸ | HTR2B | P41595 | 2/20 | 0.52 |
| ▸ | HTR5A | P47898 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HTR1F | P30939 | 1/20 | 0.52 |
| ▸ | HTR3A | P46098 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9613775 | 0.85 | HTR2A (0.56) | HTR1AHTR2AHTR2BL3MBTL1CYP1A2 | |
| SCHEMBL9228149 | 0.81 | HTR1A (0.50) | HTR1AHTR2AHTR1BHTR2CHTR2B | |
| SCHEMBL10554214 | 0.75 | HTR1A (0.70) | HTR1AHTR2AHTR6HTR7SLC6A4 | |
| SCHEMBL9513567 | 0.75 | HTR1A (0.46) | HTR1AHTR2AHTR6HTR2CHTR7 | |
| SCHEMBL9514753 | 0.74 | HTR1A (0.45) | HTR1AHTR2AHTR6HTR2CHTR7 | |
| SCHEMBL10554132 | 0.74 | DRD2 (0.59) | HTR1AHTR2AHTR6HTR2CHTR7 | |
| SCHEMBL6948769 | 0.74 | HTR2A (0.67) | HTR1AHTR2AHTR6HTR1DHTR1B | |
| SCHEMBL23069163 | 0.73 | HTR6 (0.76) | HTR1AHTR2AHTR6HTR1DHTR1B | |
| SCHEMBL32669419 | 0.73 | HTR6 (0.76) | HTR1AHTR2AHTR6HTR1DHTR1B | |
| SCHEMBL10649533 | 0.72 | HCN4 (0.62) | HTR1AHTR2AHTR6HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5250538-A | Treating CNS disorders; antiserotinin agents | NOVO NORDISK A/S (DK) | 1993-10-05 | — | — | US | claimed |
| EP-0515462-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE. | NOVO NORDISK AS (DK) | 1992-12-02 | — | — | EP | disclosed |
| US-5126363-A | Central nervous system disorders | NOVO NORDISK A/S (DK) | 1992-06-30 | — | — | US | disclosed |
| WO-1991012252-A1 | INDOLE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1991-08-22 | — | — | WO | disclosed |