SCHEMBL9600708

SCHEMBL9600708

CCCCN1CCN([C]=O)C(=O)C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.38
NPC1 O15118 4/20 0.38
RAB9A P51151 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
KDM4E B2RXH2 2/20 0.38
HPGD P15428 2/20 0.38
HSD17B10 Q99714 2/20 0.38
TSHR P16473 1/20 0.38
GRM5 P41594 2/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
PLA2G2A P14555 1/20 0.35
ALOX15 P16050 1/20 0.35
BCHE P06276 1/20 0.34
ACHE P22303 1/20 0.34
TP53 P04637 1/20 0.32
GAA P10253 1/20 0.32
GBA1 P04062 1/20 0.31
DPP4 P27487 1/20 0.30
RGS4 P49798 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9600683 0.95 PLA2G2A (0.40) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL9600835 0.93 PLA2G2A (0.41) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL9600392 0.89 L3MBTL1 (0.38) GRM5BCHEACHE
SCHEMBL4018142 0.81 GAA (0.39) SMN1; SMN2ALOX15GAA
SCHEMBL4424409 0.72 MEN1 (0.45) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL9600719 0.71 PLA2G2A (0.38) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL13572995 0.71 ALDH1A1 (0.38) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL2245662 0.71 LMNA (0.40) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL9602149 0.70 BRD4 (0.31)
SCHEMBL30778313 0.69 ALDH1A1 (0.48) ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0215435-B1 2-OXA-ISOCEPHEM COMPOUNDS, COMPOSITIONS CONTAINING SAME AND PROCESSES FOR PREPARING SAME OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1993-03-03 EP disclosed
US-4831026-A ANTIBIOTICS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1989-05-16 US disclosed
EP-0215435-A1 2-Oxa-isocephem compounds, compositions containing same and processes for preparing same OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1987-03-25 EP disclosed
US-4604460-A ANTIBIOTICS, BACTERICIDES SHIONOGI & CO., LTD. (JP) 1986-08-05 US disclosed
US-4533730-A BACTERICIDES SHIONOGI & CO., LTD. (JP) 1985-08-06 US disclosed
US-4504659-A 1-Oxadethiacepham compounds SHIONOGI & CO., LTD. (JP) 1985-03-12 US disclosed
US-4478997-A 1-Oxadethiacepham compounds SHIONOGI & CO., LTD. (JP) 1984-10-23 US disclosed
US-4443598-A ANTIBIOTICS AND INTERMEDIATES SHIONOGI & CO., LTD. (JP) 1984-04-17 US disclosed
US-4366316-A FROM OXAZOLINOAZETIDINONE AND ACID SHIONOGI & CO., LTD. (JP) 1982-12-28 US disclosed