Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.57 |
| ▸ | DRD2 | P14416 | 4/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9601882 | 0.84 | SIGMAR1 (0.56) | DRD2SIGMAR1DRD3HTR1ADRD1 | |
| SCHEMBL9602079 | 0.82 | SLC6A9 (0.55) | DRD2SIGMAR1DRD3HTR1AADRA2B | |
| SCHEMBL7794415 | 0.82 | DRD3 (0.53) | DRD2SIGMAR1DRD3HTR1AADRA2B | |
| SCHEMBL9601398 | 0.81 | DRD2 (0.50) | DRD2SIGMAR1DRD3HTR1AADRA2B | |
| Hydrochloric Acid SCHEMBL9602576 | 0.81 | GRM2 (0.52) | DRD2SIGMAR1DRD3HTR1AADRB3 | |
| Hydrochloric Acid SCHEMBL9603075 | 0.80 | SLC6A2 (0.64) | DRD2SIGMAR1DRD3HTR1AADRA2C | |
| SCHEMBL9601559 | 0.80 | SLC6A9 (0.54) | DRD2SIGMAR1DRD3HTR1AADRA2C | |
| Hydrochloric Acid SCHEMBL9602476 | 0.79 | DRD3 (0.51) | DRD2SIGMAR1DRD3HTR1AADRA2B | |
| Hydrochloric Acid SCHEMBL9602959 | 0.79 | MAPT (0.61) | DRD2SIGMAR1DRD3HTR1ADRD4 | |
| Alcohol SCHEMBL9600777 | 0.79 | KMT2A (0.54) | DRD2SIGMAR1DRD3HTR1AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308476-B1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION | Kabi Pharmacia AB (SE) | 1993-02-03 | — | — | EP | disclosed |
| US-4937245-A | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | FEX TOMAS (SE) | 1990-06-26 | — | — | US | disclosed |
| EP-0308476-A1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION. | LEO AB (SE) | 1989-03-29 | — | — | EP | disclosed |
| WO-1988007528-A1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION | AKTIEBOLAGET LEO (SE) | 1988-10-06 | — | — | WO | disclosed |