Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3137995 | 0.89 | HRH3 (0.52) | HRH3HTR1ADRD2DRD3 | |
| SCHEMBL23374607 | 0.80 | HRH3 (0.55) | HRH3HTR1ADRD2DRD3 | |
| SCHEMBL31140251 | 0.80 | HRH3 (0.55) | HRH3HTR1ADRD2DRD3 | |
| SCHEMBL3674703 | 0.79 | KCNH2 (0.72) | HRH3HTR1ADRD2DRD3HTR2A | |
| Hydrochloric Acid SCHEMBL3812906 | 0.78 | KCNH2 (0.70) | HRH3HTR1ADRD2DRD3HTR2A | |
| SCHEMBL9602778 | 0.78 | HTR2A (0.53) | HTR1ADRD2HTR2A | |
| SCHEMBL9558287 | 0.76 | SORD (0.51) | HRH3HTR1ADRD2DRD3 | |
| SCHEMBL10294622 | 0.76 | SORD (0.51) | HRH3HTR1ADRD2DRD3 | |
| SCHEMBL4447104 | 0.74 | DRD2 (0.58) | HRH3HTR1ADRD2DRD3HTR2A | |
| SCHEMBL9526311 | 0.74 | HTR1A (0.58) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309544-B1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-02-10 | — | — | EP | disclosed |
| US-5053508-A | Anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0286263-B1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4824999-A | INTERMEDIATES FOR ANTIPSYCHOTIC AND ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-04-25 | — | — | US | disclosed |
| EP-0309544-A1 | PSYCHOTROPIC BICYCLIC IMIDES. | AMERICAN HOME PROD (US) | 1989-04-05 | — | — | EP | disclosed |
| US-4804751-A | ANTIPSYCHOTIC, ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-02-14 | — | — | US | disclosed |
| US-4797488-A | N-((4-(PHENYL OR HETEROCYCLIC)PIPERAZIN-1-YL)ALKYL)-1,5-METHANOCYCLOPENT(D)AZEPINE-2,4 -DIONES; ANXIOLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0286263-A1 | Psychotropic polycyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-12 | — | — | EP | disclosed |
| WO-1988007530-A1 | PSYCHOTROPIC BICYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | disclosed |
| WO-1988007529-A1 | PSYCHOTROPIC POLYCYCLIC IMIDES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-10-06 | — | — | WO | disclosed |
| US-4748240-A | Psychotropic bicyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-31 | — | — | US | disclosed |
| US-4732983-A | Pyschotropic polycyclic imides | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-03-22 | — | — | US | disclosed |