Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9565037 | 0.95 | USP2 (0.46) | HTR7HTR1AP2RX7 | |
| SCHEMBL9564927 | 0.89 | P2RX7 (0.44) | HTR7HTR1ACHRM5CHRM1DRD2 | |
| SCHEMBL9602457 | 0.85 | CYP1A2 (0.45) | HTR1ADRD2HTR2ADRD3KCNH2 | |
| SCHEMBL9564830 | 0.83 | SSTR5 (0.43) | KCNH2LMNA | |
| Fumaric Acid SCHEMBL9565017 | 0.81 | CYP1A2 (0.48) | P2RX7LMNA | |
| SCHEMBL1152886 | 0.78 | LMNA (0.60) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL10546931 | 0.77 | GRIN1 (0.47) | HTR1ADRD2HTR2ADRD3KCNH2 | |
| SCHEMBL10552682 | 0.77 | USP2 (0.47) | HTR7HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL9564922 | 0.76 | KCNH2 (0.43) | HTR7HTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL10550233 | 0.75 | ACHE (0.51) | HTR7HTR1ADRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0206415-B1 | (4-PIPERIDINYLMETHYL AND -HETERO)PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-27 | — | — | EP | disclosed |