Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 4/20 | 0.49 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 4/20 | 0.47 |
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.47 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.47 |
| ▸ | CACNA1F known ✓ | O60840 | 3/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 3/20 | 0.47 |
| ▸ | ADRA1B known ✓ | P35368 | 3/20 | 0.47 |
| ▸ | CACNA1D known ✓ | Q01668 | 3/20 | 0.47 |
| ▸ | CACNA1S known ✓ | Q13698 | 3/20 | 0.47 |
| ▸ | CACNA1C known ✓ | Q13936 | 3/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.47 |
| ▸ | DRD1 known ✓ | P21728 | 1/20 | 0.47 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.47 |
| ▸ | MTOR known ✓ | P42345 | 1/20 | 0.47 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.46 |
| ▸ | MLNR known ✓ | O43193 | 1/20 | 0.46 |
| ▸ | ADRB1 known ✓ | P08588 | 1/20 | 0.46 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9602417 | 1.00 | DRD3 (0.49) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Fumaric Acid SCHEMBL9602977 | 0.85 | DRD3 (0.46) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Fumaric Acid SCHEMBL9602972 | 0.85 | DRD3 (0.46) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Fumaric Acid SCHEMBL9601329 | 0.84 | DRD3 (0.46) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Fumaric Acid SCHEMBL9601340 | 0.84 | DRD3 (0.46) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| SCHEMBL7794415 | 0.83 | DRD3 (0.53) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| SCHEMBL9601882 | 0.81 | SIGMAR1 (0.56) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Fumaric Acid SCHEMBL9601828 | 0.81 | KMT2A (0.46) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Fumaric Acid SCHEMBL9601839 | 0.81 | KMT2A (0.46) | DRD3DRD2SIGMAR1HTR2AADRA1A | |
| Hydrochloric Acid SCHEMBL9602476 | 0.80 | DRD3 (0.51) | DRD3DRD2SIGMAR1HTR2AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308476-B1 | BISPHENYLALKYLPIPERAZINE DERIVATIVES, A METHOD OF THEIR PREPARATION AND A PHARMACEUTICAL PREPARATION | Kabi Pharmacia AB (SE) | 1993-02-03 | — | — | EP | disclosed |
| US-4937245-A | ANTIDEPRESSANTS, ANXIOLYTIC AGENTS | FEX TOMAS (SE) | 1990-06-26 | — | — | US | disclosed |