Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TOP1 | P11387 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9602515 | 0.92 | ALDH1A1 (0.33) | DRD2TOP1MAPTKDM4EALDH1A1 | |
| SCHEMBL9602137 | 0.90 | S1PR1 (0.32) | DRD2MAPTKDM4EUSP2ALDH1A1 | |
| Fumaric Acid SCHEMBL9603164 | 0.86 | KDM4E (0.35) | DRD2MAPTKDM4EALDH1A1LMNA | |
| Fumaric Acid SCHEMBL9603160 | 0.86 | KDM4E (0.35) | DRD2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL9605374 | 0.86 | XIAP (0.33) | DRD2KDM4EALDH1A1 | |
| SCHEMBL9601994 | 0.86 | ACHE (0.40) | DRD2KDM4EALDH1A1 | |
| Fumaric Acid SCHEMBL9866670 | 0.85 | LMNA (0.34) | DRD2MAPTKDM4EALDH1A1LMNA | |
| Fumaric Acid SCHEMBL9866661 | 0.85 | LMNA (0.34) | DRD2MAPTKDM4EALDH1A1LMNA | |
| SCHEMBL9867304 | 0.84 | MAOA (0.35) | TOP1GAAMAOB | |
| Fumaric Acid SCHEMBL9603157 | 0.84 | LMNA (0.34) | DRD2MAPTKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |