Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ME1 | P48163 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.32 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10559039 | 0.88 | KMT2A (0.44) | MEN1KMT2AL3MBTL1SMN1; SMN2PDE4A | |
| SCHEMBL9601585 | 0.87 | MIF (0.36) | MEN1KMT2ASMN1; SMN2MAP3K7TAB1 | |
| SCHEMBL10562323 | 0.87 | PDE4A (0.40) | MEN1KMT2AL3MBTL1SMN1; SMN2PDE4A | |
| SCHEMBL10561260 | 0.83 | ACHE (0.36) | MEN1KMT2AL3MBTL1SMN1; SMN2PDE4A | |
| SCHEMBL10561166 | 0.82 | GAA (0.36) | MEN1KMT2ASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL10562924 | 0.81 | CES2 (0.36) | MEN1KMT2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL10560355 | 0.81 | HTT (0.38) | MEN1KMT2ASMN1; SMN2PDE4APDE4B | |
| SCHEMBL10564484 | 0.81 | PRKCZ (0.40) | MEN1KMT2AL3MBTL1SMN1; SMN2USP2 | |
| SCHEMBL10557556 | 0.81 | MAPT (0.39) | MEN1KMT2AL3MBTL1SMN1; SMN2PDE4A | |
| SCHEMBL8580740 | 0.81 | GABRP (0.43) | MEN1KMT2AL3MBTL1SMN1; SMN2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |