Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.39 |
| ▸ | ADRB1 known ✓ | P08588 | 6/20 | 0.39 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.35 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9602652 | 1.00 | CYP1A2 (0.40) | CYP1A2CYP2D6ADRB2ADRB1ADRB3 | |
| Fumaric Acid SCHEMBL9602547 | 0.88 | LMNA (0.41) | CYP1A2CYP2D6ADRB2ADRB1ADRB3 | |
| Maleic Acid SCHEMBL9602540 | 0.88 | LMNA (0.41) | CYP1A2CYP2D6ADRB2ADRB1ADRB3 | |
| Methyprylon SCHEMBL10445130 | 0.84 | CYP1A2 (0.36) | CYP1A2CYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL9601947 | 0.82 | ADRB1 (0.39) | CYP1A2CYP2D6ADRB2ADRB1ADRB3 | |
| SCHEMBL9605374 | 0.80 | XIAP (0.33) | HTR2A | |
| Fumaric Acid SCHEMBL9865911 | 0.76 | KDM4E (0.35) | LMNAHTR2A | |
| Fumaric Acid SCHEMBL9603160 | 0.74 | KDM4E (0.35) | LMNAHTR2A | |
| Fumaric Acid SCHEMBL9603164 | 0.74 | KDM4E (0.35) | LMNAHTR2A | |
| Fumaric Acid SCHEMBL9866670 | 0.74 | LMNA (0.34) | LMNASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |