Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.41 |
| ▸ | ADRB2 known ✓ | P07550 | 3/20 | 0.38 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.38 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL9602540 | 1.00 | LMNA (0.41) | LMNAMEN1KMT2ANFKB1THRB | |
| SCHEMBL9601947 | 0.95 | ADRB1 (0.39) | LMNAMEN1KMT2ANFKB1ADRB2 | |
| Fumaric Acid SCHEMBL9865911 | 0.88 | KDM4E (0.35) | LMNAMEN1KMT2AMAPK1KDM4E | |
| Maleic Acid SCHEMBL9602648 | 0.88 | CYP1A2 (0.40) | LMNAADRB2ADRB1CYP1A2ADRB3 | |
| Fumaric Acid SCHEMBL9602652 | 0.88 | CYP1A2 (0.40) | LMNAADRB2ADRB1CYP1A2ADRB3 | |
| Fumaric Acid SCHEMBL9603160 | 0.87 | KDM4E (0.35) | LMNAMAPK1KDM4E | |
| Fumaric Acid SCHEMBL9603164 | 0.87 | KDM4E (0.35) | LMNAMAPK1KDM4E | |
| SCHEMBL9602809 | 0.83 | DRD2 (0.34) | LMNAMEN1KMT2AADRB2CYP1A2 | |
| Fumaric Acid SCHEMBL9868348 | 0.82 | L3MBTL1 (0.37) | LMNAMEN1KMT2ATHRBTDP1 | |
| Fumaric Acid SCHEMBL9601552 | 0.82 | L3MBTL1 (0.37) | LMNAMEN1KMT2ATHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351435-B1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1993-08-04 | — | — | EP | disclosed |
| EP-0351435-A1 | FUSED PYRIDAZINE COMPOUNDS AND THEIR MEDICINAL USES | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |