Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.34 |
| ▸ | S1PR1 known ✓ | P21453 | 5/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.30 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9866661 | 1.00 | LMNA (0.34) | LMNAMEN1CYP3A4RECQLPMP22 | |
| Fumaric Acid SCHEMBL9603153 | 0.99 | LMNA (0.34) | LMNAMEN1CYP3A4RECQLPMP22 | |
| Fumaric Acid SCHEMBL9603157 | 0.99 | LMNA (0.34) | LMNAMEN1CYP3A4RECQLPMP22 | |
| SCHEMBL9602137 | 0.94 | S1PR1 (0.32) | LMNAS1PR1S1PR3MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL9602310 | 0.86 | S1PR1 (0.33) | LMNAMEN1KMT2AS1PR1S1PR3 | |
| SCHEMBL9602191 | 0.85 | DRD2 (0.32) | LMNAMAPTKDM4EALDH1A1GAA | |
| Fumaric Acid SCHEMBL9602825 | 0.84 | MAPK14 (0.36) | CYP3A4MAPTKDM4E | |
| Maleic Acid SCHEMBL9602819 | 0.84 | MAPK14 (0.36) | CYP3A4MAPTKDM4E | |
| Fumaric Acid SCHEMBL9603160 | 0.84 | KDM4E (0.35) | LMNAS1PR1S1PR3MAPTKDM4E | |
| Fumaric Acid SCHEMBL9867491 | 0.84 | ALDH1A1 (0.35) | LMNAMEN1CYP3A4RECQLPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5045541-A | Immunodeficiency disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-09-03 | — | — | US | disclosed |