Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31017306 | 0.85 | RAB9A (0.73) | TDP1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL4939164 | 0.85 | RAB9A (0.73) | TDP1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| Phenazine SCHEMBL94396 | 0.82 | MAPT (0.50) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| Phenazine SCHEMBL10876543 | 0.82 | MAPT (0.50) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| Phenazine SCHEMBL2873102 | 0.82 | MAPT (0.50) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL5696651 | 0.80 | TDP1 (0.77) | TDP1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL21723107 | 0.80 | TDP1 (0.77) | TDP1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9602629 | 0.78 | MEN1 (0.46) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL4063489 | 0.78 | KMT2A (0.47) | RAB9ANPC1ALDH1A1SMN1; SMN2KDM4E | |
| Benzoic Acid SCHEMBL28655261 | 0.76 | TSHR (0.61) | ALDH1A1SMN1; SMN2PKMLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250676-B1 | NON-ENZYMATIC IMMUNOHISTOCHEMICAL STAINING SYSTEM AND REAGENTS | Immunomedics, Inc. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-4792521-A | Non-enzymatic immunohistochemical staining system and reagents | IMMUNOMEDICS, INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0250676-A2 | Non-enzymatic immunohistochemical staining system and reagents | Immunomedics, Inc. (US) | 1988-01-07 | — | — | EP | disclosed |