Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL2873102 | 1.00 | MAPT (0.50) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Phenazine SCHEMBL94396 | 1.00 | MAPT (0.50) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Acridine SCHEMBL2823221 | 0.88 | ALDH1A1 (0.58) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Phenazine SCHEMBL22631548 | 0.86 | MAPT (0.55) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Phenazine SCHEMBL7095188 | 0.85 | MAPT (0.44) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL31031113 | 0.84 | NQO2 (0.49) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3129032 | 0.84 | NQO2 (0.49) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL997540 | 0.84 | NQO2 (0.49) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL9602629 | 0.84 | MEN1 (0.46) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4063489 | 0.84 | KMT2A (0.47) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102128862-B | Method for detecting redox substance in food, detection test piece and detector | EUMED BIOTECHNOLOGY CO LTD | 2014-04-23 | — | — | CN | disclosed |
| CN-102128862-A | Method for detecting redox substance in food, detection test piece and detector | EUMED BIOTECHNOLOGY CO LTD | 2011-07-20 | — | — | CN | disclosed |
| EP-0032286-B1 | METHOD FOR ANALYSIS FOR A MEMBER OF AN IMMUNOLOGICAL PAIR USING A TEST SURFACE; KIT AND TEST SURFACE MATERIAL THEREFOR | SYVA COMPANY (US) | 1986-01-08 | — | — | EP | disclosed |
| US-4391904-A | Test strip kits in immunoassays and compositions therein | SYVA COMPANY (US) | 1983-07-05 | — | — | US | disclosed |
| US-4299916-A | COLORIMETRIC ANALYSIS OF ANALYTES | SYVA COMPANY (US) | 1981-11-10 | — | — | US | disclosed |
| EP-0032286-A2 | Method for analysis for a member of an immunological pair using a test surface; kit and test surface material therefor | SYVA COMPANY (US) | 1981-07-22 | — | — | EP | disclosed |