Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.46 |
| ▸ | NQO2 | P16083 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9603204 | 0.86 | KDM4E (0.54) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| Phenazine SCHEMBL10876543 | 0.84 | MAPT (0.50) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| Phenazine SCHEMBL2873102 | 0.84 | MAPT (0.50) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| Phenazine SCHEMBL94396 | 0.84 | MAPT (0.50) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| SCHEMBL4063489 | 0.81 | KMT2A (0.47) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| SCHEMBL29856205 | 0.80 | NQO2 (0.56) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| SCHEMBL5157721 | 0.80 | NQO2 (0.56) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| SCHEMBL9603007 | 0.78 | TDP1 (0.57) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| Acridine SCHEMBL2823221 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2ANQO2KDM4EALDH1A1 | |
| SCHEMBL5157381 | 0.74 | PIK3CG (0.58) | MEN1KMT2ANQO2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0250676-B1 | NON-ENZYMATIC IMMUNOHISTOCHEMICAL STAINING SYSTEM AND REAGENTS | Immunomedics, Inc. (US) | 1993-03-10 | — | — | EP | disclosed |
| US-4792521-A | Non-enzymatic immunohistochemical staining system and reagents | IMMUNOMEDICS, INC. (US) | 1988-12-20 | — | — | US | disclosed |
| EP-0250676-A2 | Non-enzymatic immunohistochemical staining system and reagents | Immunomedics, Inc. (US) | 1988-01-07 | — | — | EP | disclosed |