Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | NQO2 | P16083 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL10876543 | 0.84 | MAPT (0.50) | KMT2AMEN1NPC1NQO2RAB9A | |
| Phenazine SCHEMBL94396 | 0.84 | MAPT (0.50) | KMT2AMEN1NPC1NQO2RAB9A | |
| Phenazine SCHEMBL2873102 | 0.84 | MAPT (0.50) | KMT2AMEN1NPC1NQO2RAB9A | |
| SCHEMBL9602629 | 0.81 | MEN1 (0.46) | KMT2AMEN1NPC1NQO2RAB9A | |
| SCHEMBL5803173 | 0.80 | KMT2A (0.67) | KMT2AATMTLR9MEN1NPC1 | |
| SCHEMBL29903456 | 0.80 | KMT2A (0.67) | KMT2AATMTLR9MEN1NPC1 | |
| SCHEMBL9603007 | 0.78 | TDP1 (0.57) | KMT2AATMMEN1NPC1NQO2 | |
| Acridine SCHEMBL2823221 | 0.78 | ALDH1A1 (0.58) | KMT2AMEN1NPC1NQO2RAB9A | |
| SCHEMBL15285573 | 0.74 | TSHR (0.54) | KMT2AMEN1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL3480837 | 0.74 | KMT2A (0.67) | KMT2AATMTLR9MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501938-B1 | ANALYSIS OF SUBSTRATE UTILIZATION BY ANIMAL OR PLANT CELLS | BIOLOG INC (US) | 2009-10-21 | — | — | EP | claimed |
| EP-1501938-A4 | COMPARATIVE PHENOTYPE ANALYSIS OF CELLS, INCLUDING TESTING OF BIOLOGICALLY ACTIVE COMPOUNDS | BIOLOG INC (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1501938-A2 | COMPARATIVE PHENOTYPE ANALYSIS OF CELLS, INCLUDING TESTING OF BIOLOGICALLY ACTIVE COMPOUNDS | BIOLOG, INC. (US) | 2005-02-02 | — | — | EP | claimed |
| WO-2003089652-A2 | COMPARATIVE PHENOTYPE ANALYSIS OF CELLS, INCLUDING TESTING OF BIOLOGICALLY ACTIVE COMPOUNDS | BIOLOG, INC. (US) | 2003-10-30 | — | — | WO | claimed |
| US-20030162164-A1 | Comparative phenotype analysis of cells, including testing of biologically active compounds | BIOLOG, INC. | 2003-08-28 | — | — | US | claimed |
| US-9274101-B2 | Methods and kits for obtaining a metabolic profile of living animal cells | BIOLOG, INC. (US) | 2016-03-01 | — | — | US | disclosed |
| EP-1501938-B1 | ANALYSIS OF SUBSTRATE UTILIZATION BY ANIMAL OR PLANT CELLS | BIOLOG INC (US) | 2009-10-21 | — | — | EP | disclosed |
| EP-1501938-A4 | COMPARATIVE PHENOTYPE ANALYSIS OF CELLS, INCLUDING TESTING OF BIOLOGICALLY ACTIVE COMPOUNDS | BIOLOG INC (US) | 2007-01-03 | — | — | EP | disclosed |
| US-20060286627-A1 | Methods and kits for obtaining a metabolic profile of living animal cells | BIOLOG INC. (US) | 2006-12-21 | — | — | US | disclosed |
| US-20050260558-A1 | Comparative phenotype analysis of cells including testing of biologically active chemicals | BIOLOG INC. (US) | 2005-11-24 | — | — | US | disclosed |
| EP-1501938-A2 | COMPARATIVE PHENOTYPE ANALYSIS OF CELLS, INCLUDING TESTING OF BIOLOGICALLY ACTIVE COMPOUNDS | BIOLOG, INC. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003089652-A2 | COMPARATIVE PHENOTYPE ANALYSIS OF CELLS, INCLUDING TESTING OF BIOLOGICALLY ACTIVE COMPOUNDS | BIOLOG, INC. (US) | 2003-10-30 | — | — | WO | disclosed |
| US-20030162164-A1 | Comparative phenotype analysis of cells, including testing of biologically active compounds | BIOLOG, INC. | 2003-08-28 | — | — | US | disclosed |