Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NQO2 | P16083 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenazine SCHEMBL10876543 | 1.00 | MAPT (0.50) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Phenazine SCHEMBL94396 | 1.00 | MAPT (0.50) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Acridine SCHEMBL2823221 | 0.88 | ALDH1A1 (0.58) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Phenazine SCHEMBL22631548 | 0.86 | MAPT (0.55) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| Phenazine SCHEMBL7095188 | 0.85 | MAPT (0.44) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL31031113 | 0.84 | NQO2 (0.49) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3129032 | 0.84 | NQO2 (0.49) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL997540 | 0.84 | NQO2 (0.49) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL9602629 | 0.84 | MEN1 (0.46) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4063489 | 0.84 | KMT2A (0.47) | MAPTNQO2ALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246485-A1 | HISTAMINE MEASUREMENT METHOD AND KIT | KIKKOMAN CORPORATION (JP) | 2021-08-12 | — | — | US | claimed |
| US-10871484-B2 | Enzymatic method for detecting polyaromatic hydrocarbons | BIOO SCIENTIFIC CORPORATION (US) | 2020-12-22 | — | — | US | claimed |
| WO-2020040113-A1 | HISTAMINE MEASUREMENT METHOD AND KIT | キッコーマン株式会社 | 2020-02-27 | — | — | WO | claimed |
| CN-109762871-A | A kind of mixture by single sulfonic acid tetrazolium and PMS derivative is used for the purposes and its detection method of microorganism detection | 杭州健昵福生物科技有限公司 | 2019-05-17 | — | — | CN | claimed |
| EP-2762883-B1 | METHOD FOR DETERMINING COLOR CHANGE IN OXIDATION-REDUCTION INDICATOR | ARKRAY INC (JP) | 2019-04-17 | — | — | EP | claimed |
| US-9598715-B2 | Method for measuring color change of oxidation-reduction indicator | ARKRAY, INC. (JP) | 2017-03-21 | — | — | US | claimed |
| US-20160054230-A1 | ENZYMATIC METHOD FOR DETECTING POLYAROMATIC HYDROCARBONS | PERKINELMER U.S. LLC | 2016-02-25 | — | — | US | claimed |
| US-20140322749-A1 | Method for Measuring Color Change of Oxidation-Reduction Indicator | ARKRAY, INC. (JP) | 2014-10-30 | — | — | US | claimed |
| EP-2762883-A1 | METHOD FOR DETERMINING COLOR CHANGE IN OXIDATION-REDUCTION INDICATOR | Arkray, Inc. (JP) | 2014-08-06 | — | — | EP | claimed |
| EP-1199560-B1 | Electrochemical method for the determination of the cell count and the biological activity | DECHEMA (DE) | 2009-09-09 | — | — | EP | claimed |
| EP-1472363-A4 | METHOD AND TEST STRIPS FOR THE MEASUREMENT OF FAT LOSS DURING WEIGHT LOSS PROGRAMS | GUPTA SURENDRA K (US) | 2008-05-28 | — | — | EP | claimed |
| EP-1472363-A2 | METHOD AND TEST STRIPS FOR THE MEASUREMENT OF FAT LOSS DURING WEIGHT LOSS PROGRAMS | GUPTA, Surendra K. (US) | 2004-11-03 | — | — | EP | claimed |
| WO-2003065875-A2 | METHOD AND TEST STRIPS FOR THE MEASUREMENT OF FAT LOSS DURING WEIGHT LOSS PROGRAMS | GUPTA SURENDRA K (US) | 2003-08-14 | — | — | WO | claimed |
| US-5036000-A | Threshold color control system | ENZYMATICS, INC. (US) | 1991-07-30 | — | — | US | claimed |
| US-12565672-B2 | Sampling method and kit for histamine measurement | KIKKOMAN CORPORATION (JP) | 2026-03-03 | — | — | US | disclosed |
| EP-3842804-B1 | SAMPLING METHOD AND KIT FOR HISTAMINE MEASUREMENT | KIKKOMAN CORP (JP) | 2025-01-22 | — | — | EP | disclosed |
| WO-2024090965-A1 | CAPSULE FOR CONTROLLED-RELEASE INSECTICIDE AND CONTROLLED-RELEASE INSECTICIDE CONTAINING SAME | 주식회사 엘지화학 | 2024-05-02 | — | — | WO | disclosed |
| US-4086142-A | Decarboxylation of endogenous serum glutamate in transaminase assays | THE DOW CHEMICAL COMPANY (US) | 1978-04-25 | — | — | US | disclosed |
| US-4024021-A | MIXING AMMONIA-FREE REAGENT | THE DOW CHEMICAL COMPANY (US) | 1977-05-17 | — | — | US | disclosed |
| US-4001089-A | METHOD FOR DETERMINATION OF TRIGLYCERIDES AND GLYCEROL | THE DOW CHEMICAL COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210246485-A1 | HISTAMINE MEASUREMENT METHOD AND KIT | HRH2, KIT, HRH3 | MAPT 4628/4885NQO2 838/4885ALDH1A1 648/4885 |
| US-12565672-B2 | Sampling method and kit for histamine measurement | HNMT, CMA1, KIT | MAPT 3279/4885NQO2 2387/4885ALDH1A1 1464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.