Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9596924 | 0.94 | MAPT (0.67) | MAPTTDP1KMT2AMEN1NPC1 | |
| SCHEMBL9603353 | 0.79 | HTR2A (0.48) | MAPTTDP1KMT2AMEN1NPC1 | |
| SCHEMBL9596806 | 0.79 | MAPT (0.51) | MAPTTDP1KMT2AMEN1NPC1 | |
| SCHEMBL21225808 | 0.77 | MAPT (0.90) | MAPTTDP1KMT2AMEN1NPC1 | |
| Tryptophanol SCHEMBL5374423 | 0.76 | KDM4E (0.68) | MAPTKMT2AMEN1GAADNMT1 | |
| Tryptophanol SCHEMBL5374419 | 0.76 | KDM4E (0.68) | MAPTKMT2AMEN1GAADNMT1 | |
| SCHEMBL9517046 | 0.76 | MAPT (0.54) | MAPTTDP1KMT2AMEN1NPC1 | |
| SCHEMBL931918 | 0.75 | KDM4E (0.66) | MAPTKMT2AMEN1GAADNMT1 | |
| SCHEMBL31383386 | 0.75 | KDM4E (0.66) | MAPTKMT2AMEN1GAADNMT1 | |
| SCHEMBL735125 | 0.74 | MAPT (1.00) | MAPTTDP1KMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5126363-A | Central nervous system disorders | NOVO NORDISK A/S (DK) | 1992-06-30 | — | — | US | disclosed |