Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | XBP1 | P17861 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22560253 | 0.81 | MAPT (0.53) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL4762874 | 0.81 | HTT (0.50) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL961773 | 0.80 | HTT (0.59) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL4138642 | 0.79 | HTT (0.68) | HTTMAPTALOX15USP2POLB | |
| SCHEMBL3712068 | 0.79 | RAB9A (0.67) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL824603 | 0.79 | CYP1A2 (0.56) | HTTPOLBKDM4ESMN1; SMN2KMT2A | |
| SCHEMBL17627043 | 0.79 | HTT (0.40) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL2899562 | 0.78 | KDM4E (0.50) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL11178856 | 0.77 | HTT (0.65) | HTTMAPTHSD17B10ALOX15USP2 | |
| SCHEMBL27930399 | 0.77 | HTT (0.59) | HTTMAPTHSD17B10ALOX15USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250998-B1 | SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN | SHISEIDO CO LTD (JP) | 2016-04-13 | — | — | EP | disclosed |
| CN-101861312-B | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines and pyridines and 3-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-2-phenyl pyridines as 5-HT7 receptor antagonists | LILLY CO ELI | 2014-09-03 | — | — | CN | disclosed |
| US-8563552-B2 | Whitening agent and skin external preparation | SHISEIDO COMPANY LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| US-8563552-B2 | Whitening agent and skin external preparation | SHISEIDO COMPANY LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| US-8563552-B2 | Whitening agent and skin external preparation | SHISEIDO COMPANY LTD. (JP) | 2013-10-22 | — | — | US | disclosed |
| EP-2155717-B1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2012-10-24 | — | — | EP | disclosed |
| US-8202873-B2 | 2-[4-(pyrazol-4-ylalkyl)piperazin-1-yl]-3-phenyl pyrazines as 5-HT7 receptor antagonists | ELI LILLY AND COMPANY (US) | 2012-06-19 | — | — | US | disclosed |
| US-20110003817-A1 | Whitening Agent And Skin External Preparation | SHISEIDO COMPANY LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20110003817-A1 | Whitening Agent And Skin External Preparation | SHISEIDO COMPANY LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| US-20110003817-A1 | Whitening Agent And Skin External Preparation | SHISEIDO COMPANY LTD. (JP) | 2011-01-06 | — | — | US | disclosed |
| EP-2250998-A1 | SKIN WHITENING AGENT AND EXTERNAL PREPARATION FOR THE SKIN | Shiseido Company, Ltd. (JP) | 2010-11-17 | — | — | EP | disclosed |
| US-20100120785-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-05-13 | — | — | US | disclosed |
| EP-2155717-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008141020-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2008-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003817-A1 | Whitening Agent And Skin External Preparation | TYR, MC1R, RTN3 | HTT 3402/4885MAPT 4460/4885HSD17B10 3068/4885 |
| US-20100120785-A1 | 2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS | HTR7, HTR2C, HTR4 | HTT 1245/4885MAPT 2476/4885HSD17B10 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.