Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.72 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.72 |
| ▸ | HTR2B | P41595 | 5/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.72 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.72 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.72 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.72 |
| ▸ | DRD2 | P14416 | 4/20 | 0.72 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.72 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.72 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.72 |
| ▸ | HTR2A | P28223 | 4/20 | 0.72 |
| ▸ | HTR2C | P28335 | 4/20 | 0.72 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.72 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.72 |
| ▸ | DRD3 | P35462 | 4/20 | 0.72 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.72 |
| ▸ | RET | P07949 | 3/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amitriptyline SCHEMBL29359365 | 0.84 | SLC6A2 (1.00) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL2877708 | 0.84 | SLC6A2 (1.00) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL7824 | 0.84 | SLC6A2 (1.00) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL28299765 | 0.82 | SLC6A2 (0.97) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL14937172 | 0.82 | SLC6A2 (1.00) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL7215255 | 0.82 | SLC6A2 (0.97) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL29356807 | 0.82 | SLC6A2 (1.00) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL41079 | 0.82 | SLC6A2 (1.00) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL3055149 | 0.81 | SLC6A2 (0.94) | HRH1SLC6A2HTR2BKCNH2CYP1A2 | |
| Amitriptyline SCHEMBL14918734 | 0.81 | SLC6A2 (0.97) | HRH1SLC6A2HTR2BKCNH2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071279-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | THE GENERAL HOSPITAL CORPORATION | 2018-03-15 | — | — | US | disclosed |
| US-20160324850-A1 | Methods and Compositions for Treating Degenerative and Ischemic Disorders | THE GENERAL HOSPITAL CORPORATION | 2016-11-10 | — | — | US | disclosed |
| US-9399032-B2 | Methods and compositions for treating degenerative and ischemic disorders | THE GENERAL HOSPITAL CORPORATION (US) | 2016-07-26 | — | — | US | disclosed |
| US-20120136007-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071279-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | PINK1, PC, PCK2 | HRH1 2432/4885SLC6A2 3061/4885HTR2B 1328/4885 |
| US-20120136007-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | PINK1, PC, PCK2 | HRH1 2432/4885SLC6A2 3061/4885HTR2B 1328/4885 |
| US-20160324850-A1 | Methods and Compositions for Treating Degenerative and Ischemic Disorders | PINK1, PC, PCK2 | HRH1 2432/4885SLC6A2 3061/4885HTR2B 1328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.