Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HCN1 | O60741 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16142405 | 0.81 | SETD7 (0.45) | SETD7HTTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13437756 | 0.79 | SETD7 (0.54) | SETD7HTTALDH1A1DRD2DRD1 | |
| SCHEMBL8311551 | 0.77 | CYP2D6 (0.42) | SETD7ALDH1A1CYP2C19DRD2DRD4 | |
| SCHEMBL4079255 | 0.76 | SETD7 (1.00) | SETD7MAOAMAOBDRD2DRD1 | |
| SCHEMBL9256562 | 0.74 | SMN1; SMN2 (0.40) | HTTALDH1A1CYP3A4CYP2C9HPGD | |
| Toluic Acid SCHEMBL30027508 | 0.74 | L3MBTL1 (0.49) | SETD7HTTALDH1A1CYP3A4CYP2C9 | |
| SCHEMBL13437764 | 0.72 | SETD7 (0.54) | SETD7HTTALDH1A1DRD2DRD1 | |
| SCHEMBL14707030 | 0.72 | ALDH1A1 (0.40) | HTTALDH1A1MAOAMAOBSMN1; SMN2 | |
| SCHEMBL13437754 | 0.71 | SETD7 (0.66) | SETD7HTTALDH1A1DRD2DRD1 | |
| SCHEMBL4548030 | 0.70 | HTT (0.77) | HTTALDH1A1CYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160324850-A1 | Methods and Compositions for Treating Degenerative and Ischemic Disorders | THE GENERAL HOSPITAL CORPORATION | 2016-11-10 | — | — | US | disclosed |
| US-9399032-B2 | Methods and compositions for treating degenerative and ischemic disorders | THE GENERAL HOSPITAL CORPORATION (US) | 2016-07-26 | — | — | US | disclosed |
| US-20120136007-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120136007-A1 | METHODS AND COMPOSITIONS FOR TREATING DEGENERATIVE AND ISCHEMIC DISORDERS | PINK1, PC, PCK2 | SETD7 2949/4885HTT 49/4885ALDH1A1 1031/4885 |
| US-20160324850-A1 | Methods and Compositions for Treating Degenerative and Ischemic Disorders | PINK1, PC, PCK2 | SETD7 2949/4885HTT 49/4885ALDH1A1 1031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.