Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95915 | 0.82 | GAA (0.43) | NPC1GAAALDH1A1MAPTMEN1 | |
| SCHEMBL5540628 | 0.81 | SLC6A4 (0.40) | RAB9ANPC1ALDH1A1MAPTMEN1 | |
| SCHEMBL2092494 | 0.79 | PTGS2 (0.46) | RAB9AALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL7183499 | 0.78 | CYP2C19 (0.33) | CYP2C19S1PR4 | |
| SCHEMBL27090 | 0.78 | CA2 (0.54) | GAAALDH1A1ACHEHPGDMAPK1 | |
| SCHEMBL1192340 | 0.77 | MAPT (0.50) | RAB9ANPC1GAAALDH1A1MAPT | |
| SCHEMBL4777646 | 0.77 | CSNK2A1 (0.56) | MEN1KMT2ASMN1; SMN2MAPK1LMNA | |
| SCHEMBL196490 | 0.76 | TTR (0.62) | RAB9ANPC1GAAALDH1A1MAPT | |
| SCHEMBL29687129 | 0.76 | TTR (0.62) | RAB9ANPC1GAAALDH1A1MAPT | |
| SCHEMBL12326172 | 0.76 | PTGS2 (0.53) | NPC1GAAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 225 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024104384-A1 | INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS | NUCMITO PHARMACEUTICALS CO. LTD. (CN) | 2024-05-23 | — | — | WO | claimed |
| CN-107787321-B | Novel5-HT2Antagonists | 安娜玛有限公司 | 2021-10-01 | — | — | CN | claimed |
| EP-3310762-B1 | NOVEL 5-HT2 ANTAGONISTS | ANAMAR AB (SE) | 2020-08-05 | — | — | EP | claimed |
| US-10647687-B2 | Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death | HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2020-05-12 | — | — | US | claimed |
| US-10544103-B2 | 5-HT2 antagonists | ANAMAR AB (SE) | 2020-01-28 | — | — | US | claimed |
| US-20180362475-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | HELMHOLTZ ZENTRUM MÜNCHEN DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2018-12-20 | — | — | US | claimed |
| US-20180155292-A1 | NOVEL 5-HT2 ANTAGONISTS | ANAMAR AB (SE) | 2018-06-07 | — | — | US | claimed |
| EP-3310762-A1 | NOVEL 5-HT2 ANTAGONISTS | Anamar AB (SE) | 2018-04-25 | — | — | EP | claimed |
| EP-3089980-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2018-01-31 | — | — | EP | claimed |
| EP-3217982-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2017-09-20 | — | — | EP | claimed |
| EP-0735819-B1 | CRYPTOPHYCINS | UNIV HAWAII (US) | 2001-07-11 | — | — | EP | claimed |
| EP-0830136-A4 | NEW CRYPTOPHYCINS FROM SYNTHESIS | UNIV HAWAII (US) | 2001-01-24 | — | — | EP | claimed |
| US-6013626-A | TO INHIBIT THE PROLIFERATION OF MAMMALIAN CELLS; ANTITUMOR AGENTS | THE UNIVERSITY OF HAWAII (US) | 2000-01-11 | — | — | US | claimed |
| CN-1183726-A | Synthetic cryptophycins | UNIV HAWAII (US) | 1998-06-03 | — | — | CN | claimed |
| EP-0830136-A1 | NEW CRYPTOPHYCINS FROM SYNTHESIS | UNIVERSITY OF HAWAII (US) | 1998-03-25 | — | — | EP | claimed |
| JP-H09510436-A | — | — | 1997-10-21 | — | — | JP | claimed |
| EP-0735819-A4 | NEW CRYPTOPHYCINS | UNIV HAWAII (US) | 1997-03-19 | — | — | EP | claimed |
| WO-1996040184-A1 | NEW CRYPTOPHYCINS FROM SYNTHESIS | UNIVERSITY OF HAWAII (US) | 1996-12-19 | — | — | WO | claimed |
| EP-0735819-A1 | NEW CRYPTOPHYCINS | UNIVERSITY OF HAWAII (US) | 1996-10-09 | — | — | EP | claimed |
| WO-1995017093-A1 | NEW CRYPTOPHYCINS | UNIVERSITY OF HAWAII (US) | 1995-06-29 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10647687-B2 | Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death | AIFM2, BAD, AIFM1 | RAB9A 4069/4885NPC1 1194/4885GAA 2647/4885 |
| US-20180362475-A1 | SPIROPYRAZINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | AIFM2, BAD, AIFM1 | RAB9A 4069/4885NPC1 1194/4885GAA 2647/4885 |
| US-10544103-B2 | 5-HT2 antagonists | HTR2B, HTR2C, HTR2A | RAB9A 2274/4885NPC1 3658/4885GAA 4672/4885 |
| US-20180155292-A1 | NOVEL 5-HT2 ANTAGONISTS | HTR2B, TPH2, HTR2C | RAB9A 2314/4885NPC1 3628/4885GAA 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.