Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TYMS | P04818 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | RORA | P35398 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6727279 | 0.86 | PGR (0.52) | PGRBRAFALDH1A1HTTPFKFB3 | |
| SCHEMBL7330777 | 0.79 | PGR (0.58) | PGRBRAFALDH1A1HTTPFKFB3 | |
| SCHEMBL259694 | 0.78 | MAPT (0.60) | PGRALDH1A1HTTPFKFB3TSHR | |
| SCHEMBL7336019 | 0.77 | BRAF (0.51) | PGRBRAFALDH1A1HTTPFKFB3 | |
| SCHEMBL31110643 | 0.77 | TSHR (0.74) | PGRALDH1A1HTTPFKFB3TSHR | |
| SCHEMBL812673 | 0.77 | TSHR (0.74) | PGRALDH1A1HTTPFKFB3TSHR | |
| SCHEMBL9616602 | 0.76 | TSHR (0.61) | PGRALDH1A1HTTPFKFB3TSHR | |
| SCHEMBL6727281 | 0.76 | PGR (0.54) | PGRBRAFALDH1A1HTTPFKFB3 | |
| SCHEMBL9616624 | 0.75 | ALDH1A1 (0.56) | PGRBRAFALDH1A1HTTPFKFB3 | |
| SCHEMBL9616665 | 0.75 | ALDH1A1 (0.56) | PGRALDH1A1HTTPFKFB3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462179-A4 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | — | 1992-03-18 | — | — | EP | claimed |
| EP-0462179-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-12-27 | — | — | EP | claimed |
| WO-1990009787-A1 | NOVEL SULFONAMIDES AS RADIOSENSITIZERS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1990-09-07 | — | — | WO | claimed |