Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 3/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11971253 | 1.00 | MAP2K1 (0.53) | MAP2K1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11971251 | 1.00 | MAP2K1 (0.53) | MAP2K1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11971054 | 1.00 | MAP2K1 (0.53) | MAP2K1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11999798 | 0.93 | ACHE (0.48) | MAP2K1ALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL17225369 | 0.79 | MAPT (0.41) | ALDH1A1KMT2ASMN1; SMN2MEN1MAOB | |
| SCHEMBL428339 | 0.79 | ALDH1A1 (0.60) | ALDH1A1KMT2ASMN1; SMN2MEN1MAPK1 | |
| SCHEMBL24306021 | 0.75 | TP53 (0.45) | KMT2AMEN1MAPK1MAOBKDM1A | |
| SCHEMBL1494251 | 0.75 | DDB1 (0.41) | ALDH1A1KMT2ASMN1; SMN2MAPK1DDB1 | |
| SCHEMBL17225910 | 0.75 | ESR2 (0.52) | KMT2AMEN1MAPK1KDM1ANPC1 | |
| SCHEMBL11971115 | 0.75 | DDB1 (0.41) | ALDH1A1KMT2ASMN1; SMN2MAPK1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174960-B2 | Compounds useful against kinetoplastideae parasites | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-11-03 | — | — | US | disclosed |
| US-20120214996-A1 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2012-08-23 | — | — | US | disclosed |
| US-5149828-A | Tetrahydropyran compounds | CIBA-GEIGY AG (CH) | 1992-09-22 | — | — | US | disclosed |
| EP-0310552-B1 | STABILIZERS FOR COLOUR PHOTOGRAPHIC RECORDING MATERIALS | CIBA-GEIGY AG (CH) | 1992-05-13 | — | — | EP | disclosed |
| US-4933271-A | Stabilizers for color photography recording materials | CIBA-GEIGY AG (CH) | 1990-06-12 | — | — | US | disclosed |
| EP-0310552-A1 | Stabilizers for colour photographic recording materials | CIBA-GEIGY AG (CH) | 1989-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214996-A1 | COMPOUNDS USEFUL AGAINST KINETOPLASTIDEAE PARASITES | TST, PDXK, TBCB | MAP2K1 1759/4885ALDH1A1 1763/4885KMT2A 962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.