Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23204988 | 0.82 | L3MBTL1 (0.60) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL10593221 | 0.82 | LPO (0.58) | KMT2AMEN1POLBMAPTKDM4E | |
| SCHEMBL9621682 | 0.82 | SIGMAR1 (0.45) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL12305079 | 0.81 | TP53 (0.50) | L3MBTL1POLBMAPTHSP90B1TP53 | |
| SCHEMBL9838297 | 0.80 | MEN1 (0.51) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL9836342 | 0.78 | RAB9A (0.48) | L3MBTL1MAPTKDM4EHSP90B1TP53 | |
| SCHEMBL10574237 | 0.78 | CYP11B1 (0.46) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL1320600 | 0.78 | ALDH1A1 (0.44) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL6348986 | 0.78 | HSD17B10 (0.51) | CYP1A2CYP2D6CYP2C19KMT2AMEN1 | |
| SCHEMBL8886835 | 0.77 | THRB (0.52) | CYP1A2CYP2D6CYP2C19KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0260814-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1992-02-05 | — | — | EP | disclosed |
| US-4992459-A | Hypotensive agents, antiulcer agents | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0212066-B1 | INTERMEDIATES USEFUL IN THE PREPARATION OF DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-11-22 | — | — | EP | disclosed |
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| US-4935438-A | Dopamine-β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1990-06-19 | — | — | US | disclosed |
| US-4912226-A | A 1-(benyzlsubstituted-),2-((1,3-dioneisoindolin-2-yl)alkyl thio-)imidazole | SMITHKLINE BECKMAN CORPORATION (US) | 1990-03-27 | — | — | US | disclosed |
| US-4882348-A | HYPOTENSIVE AGENTS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4863944-A | Dopamine-β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1989-09-05 | — | — | US | disclosed |
| WO-1989006127-A1 | 2-AMINOALKYLTHIOIMIDAZOLES AS DOPAMINE-beta-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| WO-1989006128-A1 | 2-CARBOXYALKYLTHIOIMIDAZOLES AND ESTERS THEREOF AS DOPAMINE-beta-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-07-13 | — | — | WO | disclosed |
| EP-0308573-A2 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1989-03-29 | — | — | EP | disclosed |
| EP-0125783-B1 | DOPAMINE-BETA-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1989-01-04 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| US-4772723-A | Dopamine β-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1988-09-20 | — | — | US | disclosed |
| EP-0260814-A1 | Dopamine-Beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1988-03-23 | — | — | EP | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |
| EP-0212066-A1 | Intermediates useful in the preparation of dopamine-beta-hydroxylase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1987-03-04 | — | — | EP | disclosed |
| US-4532331-A | 1-Benzyl-2-aminomethyl imidazole derivatives | SMITHKLINE BECKMAN CORPORATION (US) | 1985-07-30 | — | — | US | disclosed |
| EP-0125783-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-21 | — | — | EP | disclosed |
| EP-0125033-A1 | Dopamine-beta-hydroxylase inhibitors | SMITHKLINE BECKMAN CORPORATION (US) | 1984-11-14 | — | — | EP | disclosed |