Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 12/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HPN | P05981 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621401 | 0.94 | VCAM1 (0.52) | VCAM1PTGS1HPNMAPTALOX15 | |
| SCHEMBL9621681 | 0.86 | VCAM1 (0.46) | VCAM1PTGS1HPNMAPTALOX15 | |
| SCHEMBL9735770 | 0.81 | GAA (0.46) | VCAM1PTGS1MAPTALDH1A1GAA | |
| SCHEMBL9621830 | 0.80 | MAOA (0.32) | — | |
| SCHEMBL9328168 | 0.79 | PTGS1 (0.61) | VCAM1PTGS1HPNMAPTALOX15 | |
| SCHEMBL9621562 | 0.75 | ALOX15 (0.46) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9735154 | 0.74 | VCAM1 (0.48) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9621875 | 0.74 | VCAM1 (0.43) | VCAM1HPNMAPTALOX15SIRT5 | |
| SCHEMBL9168126 | 0.73 | ALOX15 (0.50) | VCAM1PTGS1HPNMAPTALOX15 | |
| SCHEMBL9701573 | 0.73 | HPN (0.44) | VCAM1PTGS1HPNMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162365-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5036105-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1991-07-30 | — | — | US | disclosed |
| US-4801611-A | 5-lipoxygenase inhibitors | G. D. SEARLE & CO. (US) | 1989-01-31 | — | — | US | disclosed |