Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.36 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624782 | 0.80 | KDM4E (0.65) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL9624324 | 0.78 | KDM4E (0.62) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL4368104 | 0.78 | KDM4E (0.66) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL3278153 | 0.73 | ALDH1A1 (0.60) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL9623758 | 0.73 | TDP2 (0.43) | KDM4EHSD17B10 | |
| SCHEMBL31688086 | 0.69 | TDP1 (0.50) | ALDH1A1POLBKMT2ANPC1LMNA | |
| SCHEMBL4715603 | 0.69 | TDP1 (0.50) | ALDH1A1POLBKMT2ANPC1LMNA | |
| SCHEMBL3782828 | 0.68 | ALDH1A1 (1.00) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL12253692 | 0.67 | RAB9A (0.76) | KDM4EHSD17B10ALDH1A1POLBRAB9A | |
| SCHEMBL24303332 | 0.65 | MEN1 (0.49) | KDM4EHSD17B10ALDH1A1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |