Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9626996 | 0.75 | KDM4E (0.50) | HPGDPDE3BPDE3AOPRM1MAPT | |
| SCHEMBL9628449 | 0.72 | HTR2A (0.41) | HPGDLMNAPDE3BPDE3AMAPT | |
| SCHEMBL9626856 | 0.71 | HPGD (0.50) | HPGDLMNAPDE3BPDE3AMAPT | |
| SCHEMBL8723458 | 0.68 | HPGD (0.49) | PDE4DHPGDLMNAMAPT | |
| SCHEMBL9626749 | 0.68 | PDE4D (0.38) | PDE4DHPGDLMNAHSP90AA1NPC1 | |
| SCHEMBL9096470 | 0.68 | HPGD (0.50) | HPGDPDE3BPDE3AMAPT | |
| SCHEMBL9463848 | 0.67 | PDE4D (0.60) | PDE4DLMNAMAPT | |
| SCHEMBL9626803 | 0.67 | HSD17B10 (0.48) | PDE4DHPGDLMNAPDE3BPDE3A | |
| SCHEMBL7035414 | 0.66 | HTR2A (0.39) | PDE4DLMNAHSP90AA1NPC1MAPT | |
| SCHEMBL19365882 | 0.65 | HSP90AA1 (0.52) | PDE4DHPGDHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5093339-A | Anticoagulant, hypotensive, antiangina, antiasthma, antiulcer, anti-platelet activating factor | KODAMA KABUSHIKI KAISHA (JP) | 1992-03-03 | — | — | US | disclosed |
| EP-0355689-A2 | Pyrano [f] quinoline derivatives and pharmaceutical compositions containing the same | KODAMA KABUSHIKI KAISHA (JP) | 1990-02-28 | — | — | EP | disclosed |