Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 10/20 | 0.38 |
| ▸ | BCHE | P06276 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627815 | 0.90 | BCHE (0.49) | SMN1; SMN2ACHEBCHERAB9A | |
| SCHEMBL10460150 | 0.83 | ACHE (0.39) | ACHEBCHE | |
| SCHEMBL10551546 | 0.82 | ACHE (0.51) | SMN1; SMN2ACHEBCHERAB9A | |
| SCHEMBL10460568 | 0.81 | MGLL (0.47) | ACHE | |
| SCHEMBL9627781 | 0.80 | HRH3 (0.38) | MEN1KMT2A | |
| SCHEMBL9628742 | 0.79 | TP53 (0.41) | ALDH1A1SMN1; SMN2TP53ACHEBCHE | |
| SCHEMBL9628680 | 0.78 | KMT2A (0.42) | ALDH1A1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL9628703 | 0.76 | ACHE (0.45) | ACHEBCHE | |
| SCHEMBL9628400 | 0.75 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2POLBRAB9A | |
| SCHEMBL9628968 | 0.73 | HRH3 (0.35) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |