Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.48 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9949074 | 0.90 | CA12 (0.54) | MAPTDRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL2829838 | 0.87 | LMNA (0.59) | MAPTDRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL10094750 | 0.85 | CA12 (0.49) | MAPTDRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL30134836 | 0.85 | CA12 (0.49) | CA12CA9CA2LMNAALOX5 | |
| SCHEMBL24631402 | 0.85 | CA12 (0.49) | CA12CA9CA2LMNAALOX5 | |
| SCHEMBL10094749 | 0.77 | LMNA (0.45) | MAPTDRD2DRD4CA12CA9 | |
| SCHEMBL1146089 | 0.77 | DRD2 (0.46) | MAPTDRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL4038906 | 0.76 | LMNA (0.71) | MAPTDRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL2827619 | 0.76 | LMNA (0.59) | MAPTDRD2DRD4CYP1A2CYP3A4 | |
| SCHEMBL1842504 | 0.75 | DRD2 (0.56) | MAPTDRD2DRD4CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468751-B1 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM SA (ES) | 2016-03-16 | — | — | EP | disclosed |
| EP-2468751-B1 | Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM SA (ES) | 2016-03-16 | — | — | EP | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-8580972-B2 | Processes for the preparation of 5-chloro-2-methyl-2,3,3A,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole | MEDICHEM, S.A. (ES) | 2013-11-12 | — | — | US | disclosed |
| US-8426610-B2 | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]-oxepino[4,5-c]pyrrole | MERCK SHARP & DOHME B.V. (NL) | 2013-04-23 | — | — | US | disclosed |
| EP-2154134-B1 | Process for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole. | MSD OSS BV (NL) | 2012-10-24 | — | — | EP | disclosed |
| US-8288564-B2 | Process for producing trans-dibenzoxenopyrrole compound and intermediate therefor | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| US-8288564-B2 | Process for producing trans-dibenzoxenopyrrole compound and intermediate therefor | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| US-8288564-B2 | Process for producing trans-dibenzoxenopyrrole compound and intermediate therefor | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20110046393-A1 | PROCESS FOR PRODUCING TRANS-DIBENZOXENOPYRROLE COMPOUND AND INTERMEDIATE THEREFOR | SUMITOMO CHEMICAL COMPANY LIMITED (TK) | 2011-02-24 | — | — | US | disclosed |
| US-7875729-B2 | Trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino [4,5-c]pyrrole; good isomeric purity; cyclization | SYNTHON BV (NL) | 2011-01-25 | — | — | US | disclosed |
| US-7872147-B2 | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole | N. V. ORGANON (NL) | 2011-01-18 | — | — | US | disclosed |
| US-20100152461-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12B-TETRAHYDRO-1H-DIBENZ[2,3:6,7]-OXEPINO[4,5-C]PYRROLE | SCHERING CORPORATION | 2010-06-17 | — | — | US | disclosed |
| EP-2166012-A1 | PROCESS FOR PRODUCING TRANS-DIBENZOXENOPYRROLE COMPOUND AND INTERMEDIATE THEREFOR | Sumitomo Chemical Company, Limited (JP) | 2010-03-24 | — | — | EP | disclosed |
| EP-2154134-A1 | Process for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole. | N.V. Organon (NL) | 2010-02-17 | — | — | EP | disclosed |
| EP-1710241-B1 | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole | ORGANON NV (NL) | 2009-11-04 | — | — | EP | disclosed |
| US-20080214832-A1 | Process for making asenapine | SYNTHON BV (NL) | 2008-09-04 | — | — | US | disclosed |
| US-20060229352-A1 | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole | ORGANON IRELAND LTD. (IE) | 2006-10-12 | — | — | US | disclosed |
| EP-1710241-A1 | Intermediate compounds for the prepation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole | Organon Ireland Ltd. (IE) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046393-A1 | PROCESS FOR PRODUCING TRANS-DIBENZOXENOPYRROLE COMPOUND AND INTERMEDIATE THEREFOR | DHPS, CYP4F11, COMT | MAPT 3713/4885DRD2 324/4885DRD4 99/4885 |
| US-20060229352-A1 | Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole | DHPS, ODC1, OXTR | MAPT 3847/4885DRD2 213/4885DRD4 198/4885 |
| US-20100152461-A1 | INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12B-TETRAHYDRO-1H-DIBENZ[2,3:6,7]-OXEPINO[4,5-C]PYRROLE | ODC1, DHPS, OXTR | MAPT 3807/4885DRD2 197/4885DRD4 163/4885 |
| US-20080214832-A1 | Process for making asenapine | CYP3A5, CYP3A4, CYP2C9 | MAPT 1071/4885DRD2 57/4885DRD4 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.