Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | DGKA | P23743 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9632061 | 0.90 | OPRD1 (0.50) | OPRM1MAPTDGKAALDH1A1LMNA | |
| SCHEMBL9631391 | 0.87 | OPRD1 (0.48) | OPRM1OPRK1MEN1HTR7KMT2A | |
| SCHEMBL9872824 | 0.81 | HTR2A (0.56) | ALDH1A1CYP2D6MEN1CYP3A4HTR2A | |
| SCHEMBL9870722 | 0.78 | DRD2 (0.52) | OPRM1CYP2D6MEN1HTR1AADRA2A | |
| SCHEMBL9870819 | 0.76 | KMT2A (0.51) | OPRM1ALDH1A1LMNACYP2D6MEN1 | |
| SCHEMBL10963542 | 0.75 | HTR2A (0.54) | ALDH1A1CYP2D6HRH1CYP3A4HTR2A | |
| SCHEMBL16481505 | 0.75 | OPRD1 (0.54) | OPRM1MAPTDGKAALDH1A1LMNA | |
| SCHEMBL9630470 | 0.74 | MEN1 (0.45) | MAPTALDH1A1LMNACYP2D6MEN1 | |
| SCHEMBL10932484 | 0.74 | MAPT (0.49) | MAPTALDH1A1LMNAHRH1HTR1A | |
| SCHEMBL10554622 | 0.74 | HRH3 (0.63) | HRH1HTR2AKCNH2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079249-A | Serotine antagonists at 5-HT2 level, antiallergens, antihistamines | ADIR ET COMPAGNIE (FR) | 1992-01-07 | — | — | US | disclosed |
| US-5071847-A | BIS (ARYL) ALKENE COMPOUNDS OF HOMOPIPERIDINES USEFUL AS SEROTONIN-ANTAGONISTS | ADIR ET COMPAGNIE (FR) | 1991-12-10 | — | — | US | disclosed |
| US-5028607-A | Antiserotonine agents | ADIR ET COMPAGNIE (FR) | 1991-07-02 | — | — | US | disclosed |