Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9630160 | 0.99 | HSD11B1 (0.59) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL21715106 | 0.91 | HSD11B1 (0.71) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL1597751 | 0.88 | ALDH1A1 (0.57) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL10768539 | 0.82 | ALDH1A1 (0.80) | ALDH1A1POLBL3MBTL1GAAKMT2A | |
| SCHEMBL11026630 | 0.81 | ALDH1A1 (0.54) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL8064549 | 0.81 | ALDH1A1 (0.55) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL11778138 | 0.81 | ALDH1A1 (0.55) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL21501052 | 0.80 | HSD11B1 (0.67) | HSD11B1ALDH1A1POLBL3MBTL1GAA | |
| SCHEMBL23578402 | 0.79 | BACE1 (0.48) | HSD11B1ALDH1A1POLBL3MBTL1MAPT | |
| SCHEMBL23578399 | 0.79 | BACE1 (0.48) | HSD11B1ALDH1A1POLBL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997651-A | Melphalan, antitumor | BURROUGHS WELLCOME CO. | 1991-03-05 | — | — | US | claimed |
| EP-0317281-A2 | Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-05-24 | — | — | EP | claimed |
| US-11787761-B2 | Process for the synthesis of Melphalan | INDENA S.P.A. (IT) | 2023-10-17 | — | — | US | disclosed |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2023-09-14 | — | — | US | disclosed |
| WO-2021130163-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2021-07-01 | — | — | WO | disclosed |
| EP-0317281-B1 | PHARMACEUTICAL FORMULATIONS CONTAINING MELPHALAN OR MELPHALAN HYDROCHLORIDE, AS WELL AS MELPHALAN AND MELPHALAN HYDROCHLORIDE AND PROCESSES FOR PREPARING THEM | THE WELLCOME FOUNDATION LIMITED (GB) | 1992-12-30 | — | — | EP | disclosed |
| US-4997651-A | Melphalan, antitumor | BURROUGHS WELLCOME CO. | 1991-03-05 | — | — | US | disclosed |
| EP-0317281-A2 | Pharmaceutical formulations containing melphalan or melphalan hydrochloride, as well as melphalan and melphalan hydrochloride and processes for preparing them | THE WELLCOME FOUNDATION LIMITED (GB) | 1989-05-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787761-B2 | Process for the synthesis of Melphalan | PAH, TYR, MARS1 | HSD11B1 4793/4885ALDH1A1 2246/4885POLB 1783/4885 |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | PAH, TYR, IL4I1 | HSD11B1 4789/4885ALDH1A1 2234/4885POLB 1984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.