Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | PPID | Q08752 | 3/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23578402 | 1.00 | BACE1 (0.48) | BACE1PPIDHPRT1PDCD1CD274 | |
| SCHEMBL29235935 | 0.84 | BACE1 (0.48) | BACE1TP53MEN1MAPTKMT2A | |
| SCHEMBL30034403 | 0.84 | BACE1 (0.48) | BACE1TP53MEN1MAPTKMT2A | |
| SCHEMBL9631343 | 0.79 | HSD11B1 (0.60) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL8787113 | 0.78 | ALDH1A1 (0.49) | ALDH1A1MEN1MAPTKMT2APKM | |
| Hydrochloric Acid SCHEMBL9630160 | 0.78 | HSD11B1 (0.59) | ALDH1A1MEN1MAPTKMT2ALMNA | |
| SCHEMBL3935801 | 0.74 | CTSL (0.60) | PPIDTP53ALDH1A1LMNA | |
| SCHEMBL7607209 | 0.74 | CTSL (0.60) | PPIDTP53ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL5967158 | 0.74 | ALDH1A1 (0.46) | ELANEALDH1A1MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL5967154 | 0.74 | ALDH1A1 (0.46) | ELANEALDH1A1MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4081503-B1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA SPA (IT) | 2025-07-30 | — | — | EP | disclosed |
| US-12077484-B2 | Process for the synthesis of melphalan | INDENA S.P.A. (IT) | 2024-09-03 | — | — | US | disclosed |
| CN-114845991-B | Method for synthesizing melphalan | 意迪那有限公司 | 2024-05-07 | — | — | CN | disclosed |
| US-11787761-B2 | Process for the synthesis of Melphalan | INDENA S.P.A. (IT) | 2023-10-17 | — | — | US | disclosed |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2023-09-14 | — | — | US | disclosed |
| US-20230094970-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2023-03-30 | — | — | US | disclosed |
| EP-4081503-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | Indena S.p.A. (IT) | 2022-11-02 | — | — | EP | disclosed |
| CN-114845991-A | Method for synthesizing melphalan | 因德纳有限公司 | 2022-08-02 | — | — | CN | disclosed |
| WO-2021130163-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | INDENA S.P.A. (IT) | 2021-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230094970-A1 | A PROCESS FOR THE SYNTHESIS OF MELPHALAN | PAH, IL4I1, TYR | BACE1 4654/4885PPID 2507/4885HPRT1 605/4885 |
| US-12077484-B2 | Process for the synthesis of melphalan | PAH, TYR, IL4I1 | BACE1 4646/4885PPID 2185/4885HPRT1 646/4885 |
| US-11787761-B2 | Process for the synthesis of Melphalan | PAH, TYR, MARS1 | BACE1 4594/4885PPID 2060/4885HPRT1 654/4885 |
| US-20230286901-A1 | PROCESS FOR THE SYNTHESIS OF MELPHALAN | PAH, TYR, IL4I1 | BACE1 4646/4885PPID 2185/4885HPRT1 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.