Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6522984 | 0.88 | PTGER4 (0.45) | PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL11167641 | 0.74 | ALDH1A1 (0.46) | — | |
| SCHEMBL563542 | 0.68 | KDM4E (0.35) | — | |
| SCHEMBL9321175 | 0.68 | MTNR1A (0.47) | MTNR1AMPOEGFRSRC | |
| SCHEMBL9632159 | 0.65 | EGFR (0.36) | MTNR1AEGFRSRCATM | |
| SCHEMBL6206188 | 0.65 | PTGER4 (0.58) | PTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL30341383 | 0.64 | TAAR1 (0.55) | MTNR1AMPO | |
| SCHEMBL3053811 | 0.64 | TAAR1 (0.55) | MTNR1AMPO | |
| SCHEMBL27918771 | 0.62 | MPO (0.50) | MTNR1AMPOPTGER1PTGER4PTGER3 | |
| SCHEMBL28960306 | 0.62 | PNMT (0.61) | MTNR1AMPOPTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0309626-B1 | PROCESS FOR THE PREPARATION OF DIBENZOTHIEPIN DERIVATIVE | NIPPON CHEMIPHAR CO., LTD. (JP) | 1992-05-06 | — | — | EP | disclosed |
| US-4891433-A | Process for the preparation of dibenzothiepin derivative | NIPPON CHEMIPHAR CO., LTD. (JP) | 1990-01-02 | — | — | US | disclosed |
| EP-0309626-A1 | Process for the preparation of dibenzothiepin derivative | NIPPON CHEMIPHAR CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |