Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | FTO | Q9C0B1 | 9/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMAD3 | P84022 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL384698 | 0.84 | FTO (0.54) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL19211134 | 0.80 | DHFR (0.47) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL1468956 | 0.78 | ALDH1A1 (0.40) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL20838512 | 0.76 | FTO (0.40) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL5316637 | 0.75 | FTO (0.41) | DHFRTYMSFTOALDH1A1MEN1 | |
| Dichlorofluorescein SCHEMBL21196869 | 0.74 | MAPT (0.57) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL4278233 | 0.74 | DHFR (0.39) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL1689593 | 0.73 | ALDH1A1 (0.44) | DHFRTYMSFTOALDH1A1MEN1 | |
| SCHEMBL938920 | 0.72 | DHFR (0.39) | DHFRTYMSFTOALDH1A1MEN1 | |
| Dichlorofluorescein SCHEMBL29364373 | 0.72 | MAPT (0.64) | DHFRTYMSFTOALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0185547-B1 | POLYNUCLEOTIDE HYBRIDIZATION ASSAYS EMPLOYING CATALYZED LUMINESCENCE | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-06-03 | — | — | EP | disclosed |
| US-4224407-A | USING L-LYSINE A-OXIDASE | YAMASA SHOYU KABUSHIKI KAISHA (JP) | 1980-09-23 | — | — | US | disclosed |