⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrazole SCHEMBL2254943 | 0.86 | FABP3 (0.30) | — | |
| SCHEMBL216708 | 0.82 | TRPV4 (0.38) | — | |
| SCHEMBL30010765 | 0.82 | TRPV4 (0.38) | — | |
| Tetrazole SCHEMBL27328767 | 0.74 | — | — | |
| Tetrazole SCHEMBL5862695 | 0.73 | FABP4 (0.46) | — | |
| SCHEMBL10435622 | 0.71 | L3MBTL1 (0.31) | — | |
| SCHEMBL9425114 | 0.68 | SLC9A1 (0.31) | — | |
| SCHEMBL971368 | 0.67 | L3MBTL1 (0.32) | — | |
| SCHEMBL9014773 | 0.67 | — | — | |
| SCHEMBL6893855 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128733-B1 | HUMAN INSULIN-LIKE GROWTH FACTOR (IGF) PRODUCED FROM A RECOMBINANT HOST, PROCESS, EXPRESSION VECTOR AND RECOMBINANT HOST THEREFOR, AND IGF-CONTAINING PHARMACEUTICAL COMPOSITION | GENENTECH, INC. (US) | 1992-05-06 | — | — | EP | disclosed |
| EP-0128733-A1 | Human insulin-like growth factor (IGF) produced from a recombinant host, process, expression vector and recombinant host therefor, and IGF-containing pharmaceutical composition | GENENTECH, INC. (US) | 1984-12-19 | — | — | EP | disclosed |